TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain [Pharmacology]

The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in nociceptors where, when activated by chemical or thermal stimuli, it functions as an important transducer of painful and itch-related stimuli. Although the interaction of TRPV1 with proteins that regulate its function has been previously explored, their modulation by...

Source: Proceedings of the National Academy of Sciences - February 13, 2018 Category: Science Authors: Miguel Ortiz–Renteria, Rebeca Juarez–Contreras, Ricardo Gonzalez–Ramirez, Leon D. Islas, Felix Sierra–Ramirez, Itzel Llorente, Sidney A. Simon, Marcia Hiriart, Tamara Rosenbaum, Sara L. Morales–Lazaro Tags: PNAS Plus Source Type: research