14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling.

CONCLUSIONS: Our findings suggest that inhibition of 14, 15-EET or inactivation of integrin αvβ3/FAK/PI3K/AKT pathway could serve as a novel approach to reverse EMT and cisplatin resistance in breast cancer cells.
PMID: 29426357 [PubMed - in process]

Source: Clinical Genitourinary Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Luo J, Yao JF, Deng XF, Zheng XD, Jia M, Wang YQ, Huang Y, Zhu JH Tags: J Exp Clin Cancer Res Source Type: research