Effect of short-term intensive insulin therapy on the incretin response in early type 2 diabetes.

CONCLUSION: Despite improving beta-cell function, insulin resistance and glucagonemia, short-term IIT does not change GLP-1 secretion and decreases the GIP response to an oral glucose challenge in early type 2 diabetes. Thus, the beneficial impact of this therapy on glucose homeostasis is not attributable to its effects on incretin secretion.
PMID: 29395808 [PubMed - as supplied by publisher]

Source: Diabetes and Metabolism - January 11, 2018 Category: Endocrinology Authors: Choi H, Kramer CK, Zinman B, W Connelly P, Retnakaran R Tags: Diabetes Metab Source Type: research