Cutting out meat may stop breast cancer spreading
Researchers from the Cancer Research UK Cambridge Institute found feeding mice with breast cancer a diet low in the the amino acid asparagine reduces their tumours' ability to spread.
Roche today announced the phase III KATHERINE study met its primary endpoint, showing Kadcyla ® (trastuzumab emtansine) as a single agent significantly reduced the risk of disease recurrence or death (invasive disease-free survival, iDFS) compared to Herceptin® (trastuzumab) as an adjuvant (after surgery) treatment in people with HER2-positive early breast cancer (eBC) who have residual di sease (pathological invasive residual disease in the breast and/or axillary nodes) present following neoadjuvant (before surgery) treatment.
(Georgetown University Medical Center) A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.
AbstractOptimization of axillary staging among patients converting from clinically node-positive disease to clinically node-negative disease through primary systemic therapy is needed. We aimed at developing a nomogram predicting the probability of positive axillary status after chemotherapy based on clinical/pathological parameters. Patients from study arm C of the SENTINA trial were included. Univariable/multivariable analyses were performed for 13 clinical/pathological parameters to predict a positive pathological axillary status after chemotherapy using logistic regression models. Odds ratios and 95%-confidence-interva...
ConclusionsHigh pre-NAC TIL levels were significantly predictive of pCR in BC, and can act as a surrogate marker for predicting therapeutic effects of a TCHP regimen for HER2-positive BC. Post-NAC TILs in residual disease were a new prognostic marker of risk stratification for long-term survival.
Journal of Magnetic Resonance Imaging, EarlyView.
Target-based therapeutic matching of phase I trials in patients with metastatic breast cancer in a tertiary referral centre, Published online: 15 October 2018; doi:10.1038/s41416-018-0290-8Target-based therapeutic matching of phase I trials in patients with metastatic breast cancer in a tertiary referral centre
Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells, Published online: 15 October 2018; doi:10.1038/s41416-018-0284-6Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells
ConclusionsThe results of this study indicate that lymphovascular invasion is associated with axillary metastasis, based on an SLN biopsy.
Authors: Hwang KT, Han W, Lee SM, Choi J, Kim J, Rhu J, Kim YA, Noh DY Abstract Purpose: The prognostic influence of 3-dimensional tumor volume (Tv) on breast cancer compared to conventional 1-dimensional tumor size (T) was investigated. Methods: Analysis was performed on a cohort of 8,996 primary breast cancer patients who were initially diagnosed with TNM stage I-III. Tumor size was defined as the maximum tumor dimension, and Tv was calculated by the equation of (4π × r1 × r2 × r3)/3; r1, r2, and r3 were defined as half of the largest, intermediate, and shortest dimension of the tumor, re...