Implementation of a 5-Minute Magnetic Resonance Imaging Screening Protocol for Prostate Cancer in Men With Elevated Prostate-Specific Antigen Before Biopsy

Conclusions A 5-minute MR screening protocol for prostate cancer in men with elevated prostate-specific antigen levels before biopsy is applicable for clinical routine with similar diagnostic performance as the full diagnostic mpMRI approach.
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research

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This study applied a dual-agent, 13C-pyruvate and 13C-urea, hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) and multi-parametric (mp) 1H magnetic resonance imaging (MRI) approach in the transgenic adenocarcinoma of mouse prostate (TRAMP) model to investigate changes in tumor perfusion and lactate metabolism during prostate cancer development, progression and metastases, and after lactate dehydrogenase-A (LDHA) knock-out. An increased Warburg effect, as measured by an elevated hyperpolarized (HP) Lactate/Pyruvate (Lac/Pyr) ratio, and associated Ldha expression and LDH activity were significantly higher in...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractPurposeTo study the detection of clinically significant prostate cancer (PCa) by readers with different experience, comparing performance with biparametric magnetic resonance imaging (bmMRI) and with the reference multiparametric (mpMRI).MethodsRetrospective analysis of 68 patients with mpMRI of the prostate at 1.5 Tesla using a 32 phased-array coil. Forty-five patients (cases) underwent radical prostatectomy, whereas 23 (controls) had a negative prostate biopsy and  ≥ 2.5 years of negative follow-up. Six observers (two with 1000 cases interpreted, two with 300, two with 100) performed the ana...
Source: Abdominal Imaging - Category: Radiology Source Type: research
AbstractLocal recurrent prostate cancer after radical treatment is found in the majority of men with a rising PSA. Salvage treatment procedures for recurrent disease, such as radiation therapy and ablative procedures, can provide long-term responses in well-selected cases. Prostate magnetic resonance imaging (MRI) allows diagnosis and staging, and the value provides information on treatment selection, treatment planning and treatment guidance in local recurrent prostate cancer.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Abstract Focal therapy (FT) should have the same oncological efficacy as whole gland therapy with fewer side effects. Precise diagnosis with PI-RADS v2 standard multiparametric magnetic resonance imaging (MRI) and fusion or template biopsy is a basic prerequisite. Numerous ablation technologies and treatment strategies have been developed, including hemiablation. Treatment success is still inconsistently defined. The only large randomized study available compares one of the procedures to standard therapy. Therefore, even in 2019, FT must still be regarded as experimental and should only be carried out within ...
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
AbstractPurpose of ReviewProstate cancer (PCA) detection and diagnosis has rapidly changed in recent years, with medical imaging playing an instrumental component. Multiparametric magnetic resonance imaging (MRI) has led to an alternative diagnostic pathway for patient triage and diagnosis. Ultrasound (US) is already essential to this pathway, and development of new US technologies ensures it will assume an even more important role.Recent FindingsConventional US is widely used for anatomic guidance during prostate biopsy, but has low PCA detection rates. Ultrasound elastography and contrast-enhanced US are promising for im...
Source: Current Radiology Reports - Category: Radiology Source Type: research
To assess whether there is a significant difference in perfusion parameters between benign and malignant prostatic lesions, focusing on semi-quantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and presence of late gadolinium enhancement (LGE).
Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
Objectives The aim of the study was to determine the quantitative T2 values in prostate tissue and evaluate them for detection and grading of prostate cancer. Materials and Methods After approval from the local ethics committee, morphological T2-weighted (T2w) images, apparent diffusion coefficient (ADC) maps from diffusion-weighted images, quantitative T2 maps, and calculated T2w images from 75 men (median age, 66.3 years; median PSA, 8.2 ng/mL) were acquired at 3 T magnetic resonance imaging (MRI). Data were retrospectively evaluated for their distinction between prostate pathologies. Eight hundred fifty-seven area...
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
AbstractActive surveillance is a good management option for some men with non-metastatic prostate cancer. In this review, we examine the evidence for several topics related to active surveillance. We examine: (1) which patients should be eligible for active surveillance, (2) what follow-up (monitoring) protocols should be used for men on surveillance, (3) what is the role of prostate magnetic resonance imaging (MRI) for men on surveillance, and (4) what is the prognosis for men who choose surveillance compared to radical treatment. In many instances, the evidence is evolving or lacking. In these situations, we highlight th...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 1 February 2019Source: European UrologyAuthor(s): Jonathan E. Shoag, Jeffrey J. Tosoian, Simpa S. Salami, Christopher E. Barbieri
Source: European Urology - Category: Urology & Nephrology Source Type: research
The ascendance of prostate magnetic resonance imaging (MRI) coincided with a popular reckoning about years of overdiagnosis and overtreatment of low-grade prostate cancer.1 Prostate MRI has been heralded as a solution to improve accuracy when diagnosing and staging prostate cancer with 2 primary advantages: (1) detecting occult, high-grade cancer in men who would otherwise be missed, allowing timely treatment, and (2) ruling out aggressive disease in men with ostensibly low-risk cancers allowing greater confidence in avoiding treatment.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
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