PPAR γ-targeting potential for radioprotection.

PPARγ-targeting potential for radioprotection. Curr Drug Targets. 2018 Jan 30;: Authors: Kaur S, Nag A, Singh AK, Sharma K Abstract Peroxisomal proliferator receptor gamma (PPARγ) is a class of nuclear hormone receptor family involved in insulin sensitization. In addition, PPARγ has a key role in the protection against oxidative stress and inflammation through regulation of NFkappaB levels and cross-talk with the Nrf-2 pathway. Also, its role in the modulation of immune response is substantial. Radiation-induced oxidative stress is the sole determinant of damage to hematopoietic, gastrointestinal system and immune system suppression. Uncontrolled exposure to normal cells during radiotherapy raises the demand for novel and efficient radioprotectors. In this review, we will present an overview of the involvement of PPARγ in radiation-induced damage and inflammation with major emphasis on whether PPARγ can serve as a suitable radiomodification target. PMID: 29384061 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research