Study of the placentae of patients with neuromyelitis optica spectrum disorder

The objective of this study was to explore whether AQP4-IgG influences pregnancy by affecting AQP4 expression and inducing placental inflammation in patients with NMOSD. We prospectively collected clinical data from six pregnant AQP4-IgG-seropositive NMOSD patients and their infants, and investigated AQP4 expression and placental inflammatory infiltration by comparing hematoxylin and eosin and immunohistochemical (AQP1, AQP4, C5b-9, IgG, CD3, CD8, CD20, and CD68) staining results with three normal controls.

Source: Journal of the Neurological Sciences - February 1, 2018 Category: Neurology Authors: Yanyu Chang, Yaqing Shu, Xiaobo Sun, Tingting Lu, Chen Chen, Ling Fang, Dan He, Chengfang Xu, Zhengqi Lu, Xueqiang Hu, Lisheng Peng, Allan G. Kermode, Wei Qiu Source Type: research