Cholera toxin enhances IL-17A production in both CD4+ and CD8+ cells via a cAMP/PKA-mediated IL-17A promoter activation.

In conclusion, our data suggest that CT induces an IL-17A-dominated immune microenvironment via cAMP/PKA/CREB signaling pathway. Our study also highlights the potentials of CT and cAMP in modulating Th17 responses in vivo. This article is protected by copyright. All rights reserved. PMID: 29377102 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research