Food and feed safety of DAS-444 Ø6-6 herbicide-tolerant soybean

Publication date: April 2018 Source:Regulatory Toxicology and Pharmacology, Volume 94 Author(s): Rod A. Herman, Ricardo D. Ekmay, Barry W. Schafer, Ping Song, Brandon J. Fast, Sabitha Papineni, Guomin Shan, Daland R. Juberg DAS-444Ø6-6 soybean was genetically engineered (GE) to withstand applications of three different herbicides. Tolerance to glufosinate and glyphosate is achieved through expression of the phosphinothricin acetyltransferase (PAT) and double-mutated maize 5-enolpyruvyl shikimate-3-phosphate synthase (2mEPSPS) enzymes, respectively. These proteins are expressed in currently commercialized crops and represent no novel risk. Tolerance to 2,4-dichlorophenoxyacetic acid (2,4-D) is achieved through expression of the aryloxyalkanoate dioxygenase 12 (AAD-12) enzyme, which is novel in crops. The safety of the AAD-12 protein and DAS-444Ø6-6 event was assessed for food and feed safety based on the weight of evidence and found to be as safe as non-GE soybean.
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research