Protective potential of Tetrapleura tetraptera against trona ( kaun )-induced hepatic injury in rat models

AbstractThe antioxidant protective effect of the fruits and peels ofTetrapleura tetraptera were investigated in trona (kaun)-induced oxidative injuries in male albino rats. The peels and fruits ofT. tetraptera were air-dried and extracted with ethanol. The concentrated extracts were subjected to FTIR spectroscopy analysis to identify their chemical functional groups. Five groups of six rats each were pretreated with trona (500  mg/kg bw) for 7 days, while a sixth group was administered water only which served as normal control. Four of the pretreated groups were subjected to posttreatment withT. tetraptera extracts, while the fifth served as negative control. At the end of the experiment, their hepatic, kidney, and intestinal tissues were assessed for catalase activity and malondialdehyde (MDA) level. Aspartate transaminase (AST) and alanine transaminase (ALT) levels were analyzed in blood serum. While histopathology was carried out on hepatic tissues. FTIR spectroscopy of the extracts revealed amines, alcohols, carboxylic acids, esters, ethers, aromatics, alkanes, aldehydes, ketones, phenols, and amides as the functional groups. Ingestion of trona caused significant (p <  0.05) increase in all studied biological parameters in all tissues. These were significantly (p <  0.05) reversed to near normal after treatment with both extracts. Histopathology revealed reduction in trona-induced lesions and alterations in hepatic tissue after treatment with the extracts....
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research