GSE109346 The role of metallothionenins and Slc genes in accommodation in ABOincompatible transplantation

Contributors : Petra Hruba ; Ondrej Viklicky ; Zdenek Krejcik ; Viktor Stranecky ; Faikah Gueler ; Alena Parikova ; Janka Slatinska ; Mariana Wohlfahrtova ; Ilja Striz ; Jiri Fronek ; Eva Honsova ; Jana MaluskovaSeries Type : Expression profiling by arrayOrganism : Homo sapiensBoth present hemagglutinins and anti HLA antibodies bind to vascular endothelial cells in kidney transplantation, however in some patients this antibody-endothelial interaction is not associated with obvious tissue injury. Mechanisms of this phenomenon called accommodation remain poorly understood. Illumina Human HT-12 v4 Expression BeadChips whole renal transcriptome was evaluated in 3-months protocol biopsies with isolated C4d staining in otherwise stable ABO incompatible and HLA incompatible DSA positive kidney grafts (n=18) as well as in C4d negative HLA compatible grafts with normal histological findings (n=8). Top differently regulated genes were further validated using RT-qPCR at the independent patient cohort (n=24). GO terms with the highest fold enrichment revealed by gene annotation analysis of deregulated genes between ABOi and HLAi groups were represented by cadmium ion binding (p
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research