Patched 1 Expression Correlates with Biochemical Relapse in High-Risk Prostate Cancer Patients.

In this study potential associations between Hh pathway protein expression and clinico-pathological factors, including time to biochemical recurrence (BCR), were investigated using a tissue microarray constructed from benign and malignant prostate samples from 75 predominantly high-risk PCa patients who underwent radical prostatectomy. Hh signaling activity was found to differ between benign and malignant prostate tissue, with a greater amount of active Hh signaling present in malignant than benign prostate epithelium. High expression of PTCH1 in malignant prostate epithelium was found to be an independent predictor of BCR in high-risk PCa patients. GLI1 may potentially represent a clinically useful biomarker of an aggressive tumor phenotype. Evaluation of Hh signaling activity in PCa patients may be useful for risk-stratification, and epithelial PTCH1 expression in particular may be a prognostic marker for BCR in high-risk PCa patients. PMID: 29339090 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29339090?dopt=Abstract

Source: The American Journal of Pathology - January 12, 2018 Category: Pathology Authors: Gonnissen A, Isebaert S, Perneel C, McKee CM, Van Utterbeeck F, Lerut E, Verrill C, Bryant RJ, Joniau S, Muschel RJ, Haustermans K Tags: Am J Pathol Source Type: research