Alterations of global DNA methylation and DNMT expression in T and B lymphocytes from patients with newly diagnosed AITD after treatment: A follow-up study.

CONCLUSIONS: Hyperthyroid patients with newly diagnosed GD had global hypomethylation and lower DNMT1 expression in T and B lymphocytes. The results provide the first demonstration that antithyroid drugs or radioiodine treatment restores global DNA methylation and DNMT1 expression with concurrent relief of hyperthyroidism. PMID: 29336230 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research