Expression of Elafin in Dermatitis Herpetiformis

Conclusion: Under normal circumstances, keratinocytes overexpress elafin to downregulate a neutrophil mediated inflammatory response. The deficient expression of elafin in the aforementioned probed DH specimens correlates with previous similar elafin underexpression in intestinal samples of active CD. These histological findings suggest that these 2 gluten mediated disorders carry an abnormal elafin underexpression during disease activity.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: CME Article Source Type: research