Women's preference for non ‐invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study

ConclusionIn a setting where reporting times are similar and there is no cost difference between options, approximately 60% of women with pregnancies classed as HR would opt for NIPT, offering simple but limited aneuploidy assessment, over a diagnostic procedure with comprehensive and more detailed assessment. Tweetable abstract60% of pregnant Chinese women prefer NIPT over CMA when screened as high risk for Down syndrome.
Source: BJOG: An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: Original Article Source Type: research

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This study aims to investigate the effects of progesterone on the possible changes in nuchal translucency (NT) levels for patients diagnosed with threatened miscarriage. The study group was composed of 125 patients diagnosed with threatened miscarriage and taking 400 mg/day micronized orally progesterone at least for two weeks, the control group was composed of 160 healthy pregnant women not taking any progesterone. Crown rump length (CRL) NT thickness, Pregnancy-associated plasma protein-A (PAPP-A), free beta human chorionic gonadotropin (Beta-HCG) levels of patients were measured for assessment of aneuploidy risk....
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
(CNN) — Natalie Dedreux has spent months campaigning against a plan to make a blood test for Down syndrome free in Germany. While its proponents say the prenatal test is a safer alternative to current procedures and should be available to everyone, Dedreux believes it will lead to people like her being “sorted out.” Dedreux, a 20-year aspiring journalist from Cologne, has the condition. “I am worried that if pregnant women find out their baby has Down syndrome, they will decide against us …. because they are scared,” she wrote on her blog. She has attended protests against the plan and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Down Syndrome Source Type: news
Abstract The field of prenatal screening and diagnosis has undergone enormous progress over the past four decades. Most of this period has been characterized by gradual improvements in the technical and public health aspects of prenatal screening for Down syndrome. Compared to the direct analysis of fetal cells from amniocentesis or chorionic villus sampling, noninvasive approaches using maternal blood or ultrasound have the great advantage of posing no risk of miscarriage to the pregnancy. Recent advances in molecular genetics and DNA sequencing have revolutionized both the accuracy and the range of noninvasive t...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
This randomized trial compares the effects of maternal Down syndrome screening using plasma cell-free DNA (cfDNA) measures vs invasive screening on miscarriage rates among pregnant women at high risk of trisomy 21 based on first-trimester combined screening.
Source: JAMA - Category: General Medicine Source Type: research
ConclusionResults in our case series suggest that levodopa, rasagiline, pramipexole, and ropinirole alone or in combination with each other may be considered relatively safe during pregnancy. Expected benefits and risks should be considered when prescribing anti-PD medication in pregnant women.
Source: Journal of Neurology - Category: Neurology Source Type: research
CONCLUSIONS: As safety seems to affect the majority of pregnant couples' choice behaviour, thorough pre-test counselling by trained health professionals is of paramount importance. FUNDING: Aarhus University and The Foundation of 17-12-1981. TRIAL REGISTRATION: This study was registered with the Danish Data Protection Agency (1-16-02-586-13/ 2007-58-0010). PMID: 29726320 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
Pregnant women in Wales will become the first in the UK to receive a non-invasive test for Down's syndrome.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Navigating through the many different pre-natal blood tests can be confusing. Names like Sequential Screening, NIPT, and Carrier Screening meant nothing to me before being pregnant. As my doctor explained the different blood tests, I found myself being even more confused. I just wanted to know which blood test was the best option for my baby and me. As you enter your second trimester and prepare to take multiple blood tests, it’s best to do your research beforehand. This way you’ll know what to expect and won’t be overwhelmed by the different options. Here is a breakdown of the different blood tests: Sequ...
Source: Cord Blood News - Category: Perinatology & Neonatology Authors: Tags: pregnancy Source Type: blogs
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Source: BJOG: An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: Mini ‐commentary Source Type: research
Conclusions: Contrary to expectation, higher PBDE concentrations were associated with decreased odds of ASD and ID, though not in girls. These findings require confirmation but suggest potential sexual dimorphism in associations with prenatal exposure to BFRs. https://doi.org/10.1289/EHP1079 Received: 09 September 2016 Revised: 18 May 2017 Accepted: 25 May 2017 Published: 30 August 2017 Address correspondence to K. Lyall, 3200 Market St., Suite 560, A.J. Drexel Autism Institute, Philadelphia, PA 19104 USA. Telephone: (215) 571-3215. Email: kld98@drexel.edu Supplemental Material is available online (https://doi.org/10...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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