Right putamen and age are the most discriminant features to diagnose Parkinson's disease by using 123I-FP-CIT brain SPET data by using an artificial neural network classifier, a classification tree (ClT).

Right putamen and age are the most discriminant features to diagnose Parkinson's disease by using 123I-FP-CIT brain SPET data by using an artificial neural network classifier, a classification tree (ClT). Hell J Nucl Med. 2017 Sep-Dec;20 Suppl:165 Authors: Cascianelli S, Tranfaglia C, Fravolini ML, Bianconi F, Minestrini M, Nuvoli S, Tambasco N, Dottorini ME, Palumbo B Abstract OBJECTIVE: The differential diagnosis of Parkinson's disease (PD) and other conditions, such as essential tremor and drug-induced parkinsonian syndrome or normal aging brain, represents a diagnostic challenge. 123I-FP-CIT brain SPET is able to contribute to the differential diagnosis. Semiquantitative analysis of radiopharmaceutical uptake in basal ganglia (caudate nuclei and putamina) is very useful to support the diagnostic process. An artificial neural network classifier using 123I-FP-CIT brain SPET data, a classification tree (CIT), was applied. CIT is an automatic classifier composed of a set of logical rules, organized as a decision tree to produce an optimised threshold based classification of data to provide discriminative cut-off values. We applied a CIT to 123I-FP-CIT brain SPET semiquantitave data, to obtain cut-off values of radiopharmaceutical uptake ratios in caudate nuclei and putamina with the aim to diagnose PD versus other conditions. SUBJECTS AND METHOD: We retrospectively investigated 187 patients undergoing 123I-FP-CIT brain SPET (Millenium VG, G.E.M.S.) wi...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

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In this study, we generated DA neurons from PARK2 patient-specific, isogenic PARK2 null and PARK6 patient-specific induced pluripotent stem cells and found that these neurons exhibited more apoptosis and greater susceptibility to rotenone-induced mitochondrial stress. From phenotypic screening with an FDA-approved drug library, one voltage-gated calcium channel antagonist, benidipine, was found to suppress rotenone-induced apoptosis. Furthermore, we demonstrated the dysregulation of calcium homeostasis and increased susceptibility to rotenone-induced stress in PD, which is prevented by T-type calcium channel knockdown or a...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Conditions:   Exercise;   Parkinson Disease Intervention:   Other: Exercise Sponsor:   Sun Life Financial Movement Disorders Research and Rehabilitation Centre Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsPD significantly impacted the affordances for aperture negotiation. Such altered perceptual affordances may contribute to gait pattern changes in people with PD when walking through doorways. These findings suggest that some of the motor symptoms in PD might have a perceptual underpinning.
Source: Neuropsychologia - Category: Neurology Source Type: research
The workshop aims to provide a kaleidoscopic view of the latest research, treatments, and ways forward towards better understanding and being able to cure Parkinson's disease. The workshop aims to moreover look at how greater funding could enable such steps forward, both clinically and politically - especially in light of negotiations on the upcoming research framework programme, Horizon Europe. Finally, the session will also explore the possible links between toxins (herbicides and pesticides) with the disease. Parkinson’s is a progressive neurodegenerative disorder having no known cause, typically with onset later...
Source: EUROPA - Research and Innovation: Events - Category: Research Tags: Health - D72D1707-FE0F-3C39-4E55830C194C2E7C Science with and for Society - D72D5ADE-E17B-80FF-16E7D49AA38B1B23 Life sciences - 7DB37216-D9A7-5F19-1F4B02B58D353C4B Horizon 2020 - 719491AD-9C69-558D-B05B8AC79345ED08 Source Type: events
Sensors, Vol. 18, Pages 3533: Novelty Detection using Deep Normative Modeling for IMU-Based Abnormal Movement Monitoring in Parkinson’s Disease and Autism Spectrum Disorders Sensors doi: 10.3390/s18103533 Authors: Nastaran Mohammadian Rad Twan van Laarhoven Cesare Furlanello Elena Marchiori Detecting and monitoring of abnormal movement behaviors in patients with Parkinson’s Disease (PD) and individuals with Autism Spectrum Disorders (ASD) are beneficial for adjusting care and medical treatment in order to improve the patient’s quality of life. Supervised methods commonly used in the ...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Tarquin P. Stott, Erik G. N. Olson, Rachel H. Parkinson, and John R. Gray Adaptive collision avoidance behaviours require accurate detection of complex spatiotemporal properties of an object approaching in an animal's natural, 3-dimensional environment. Within the locust, the lobula giant movement detector (LGMD) and its postsynaptic partner, the descending contralateral movement detector (DCMD) respond robustly to images that emulate an approaching 2-dimensional object and exhibit firing rate modulation correlated with changes in object trajectory. It is not known how this pathway responds to visual expansion of a 3-dimen...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: RESEARCH ARTICLE Source Type: research
Sensors, Vol. 18, Pages 3549: Gait Study of Parkinson’s Disease Subjects Using Haptic Cues with A Motorized Walker Sensors doi: 10.3390/s18103549 Authors: Minhua Zhang N. Sertac Artan Huanying Gu Ziqian Dong Lyudmila Burina Ganatra Suzanna Shermon Ely Rabin Gait abnormalities are one of the distinguishing symptoms of patients with Parkinson’s disease (PD) that contribute to fall risk. Our study compares the gait parameters of people with PD when they walk through a predefined course under different haptic speed cue conditions (1) without assistance, (2) pushing a conventional rolling wal...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Publication date: Available online 17 October 2018Source: International Review of NeurobiologyAuthor(s): Hugo C. Baggio, Carme JunquéAbstractFunctional magnetic resonance imaging (fMRI) has been used to study the neural bases of cognitive deficits in Parkinson's disease for several years. Traditionally, task-based fMRI has been applied to study specific cognitive functions, providing information on disease-related alterations and regarding the physiological bases of normal cognition, the dopaminergic system, and the frontostriatal circuits. More recently, functional connectivity techniques using resting-state fMRI d...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 16 October 2018Source: International Review of NeurobiologyAuthor(s): Julie M. Hall, Simon J.G. LewisAbstractCognitive impairment is one of the most salient non-motor symptoms of Parkinson's disease (PD). Cognitive decline poses a significant burden on the patient as well as the caregiver and a better understanding of the underlying pathological processes will aid in directing disease-specific treatment. In recent years, significant progress in the understanding of the underlying mechanisms of cognition in PD has been made using neuroimaging modalities. In this review, we will discuss the...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 17 October 2018Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Zhi Dong Zhou, Ji Chao Tristan Lee, Eng King TanAbstractMutations of F-box only protein 7 (FBXO7) gene are associated with a severe form of autosomal recessive juvenile Parkinson's disease (PD) (PARK15) with clinical features of Parkinsonian-Pyramidal syndrome (PPS). FBXO7 is an adaptor protein in SCFFBXO7 ubiquitin E3 ligase complex that recognizes and mediates degradative or non-degradative ubiquitination of substrates. The FBXO7 protein can regulate cell cycle, proliferation, mitochondrial and proteasome fu...
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research
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