Quality of Life From Canadian Cancer Trials Group MA.17R: A Randomized Trial of Extending Adjuvant Letrozole to 10 Years.

Conclusion No clinically significant differences were seen in overall QOL measured by the SF-36 summary measures and MENQOL between the letrozole and placebo groups. The data indicate that continuation of aromatase inhibitor therapy after 5 years of prior treatment in the trial population was not associated with a deterioration of overall QOL. PMID: 29328860 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research

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Background: The aim of this study was to investigate the immunohistochemical expression of ribosomal protein (RP) S6-pS240 in non-special type invasive breast cancer in relation to other prognostic markers and gain new insights to facilitate more individualized treatment.Methods: The following clinical and histopathological parameters of 120 patients were determined: S6-pS240 expression, age, menopausal status, tumor size and grade, TNM stage, Nottingham Prognostic Index (NPI), lymph node stage, estrogen and progesterone receptor (ER/PR) expression, HER2/neu amplification, lymphovascular invasion, and proliferative index a...
Source: Breast Care - Category: Cancer & Oncology Source Type: research
Conditions:   Genitourinary Syndrome of Menopause;   Vaginal Atrophy;   Breast Cancer;   Dyspareunia Intervention:   Device: Microablative Fractional CO2 Laser Therapy Sponsor:   National and Kapodistrian University of Athens Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Research, published inCancer, suggests that overweight women who lose weight after menopause are at a lower risk of developing breast cancer. Reuters
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Sleep has been closely linked to breast cancer risk. However, the association between sleep and breast cancer prognosis remains unclear. The aim of this study was to evaluate the separate and joint effects of multiple sleep characteristics on breast cancer prognosis among Chinese women.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Original Article Source Type: research
(Reuters Health) - Older women who lose weight may have a lower risk of developing invasive breast cancer than those who maintain or gain weight, a large U.S. study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
ConclusionsThe natural, age-related reduction in bone density is exacerbated by breast cancer active AI treatment. Future research should focus on investigating screening adherence-related barriers/facilitators and effective strategies to bring practice in line with agreed standards.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Abstract Vasomotor symptoms (VMS) are the primary menopausal symptoms, occurring in up 80% of women and peaking around the final menstrual period. The average duration is 10 years, longer in women with an earlier onset. Compared with non-Hispanic white women, black and Hispanic women are more likely and Asian women are less likely to report VMS. Risk factors include greater body composition (in the early stage of menopausal transition), smoking, anxiety, depression, sensitivity to symptoms, premenstrual syndrome, lower education, and medical treatments, such as hysterectomy, oophorectomy, and breast cancer-re...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Obstet Gynecol Clin North Am Source Type: research
(Natural News) Post-menopausal women with a normal body mass index (BMI), but who have high amounts of body fat are more prone to breast cancer, a study presented to the American Association for Cancer Research found. This means that for post-menopausal women, it is not enough to be slim but to be fit as well...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
ConclusionIn this study, we did not find a significant association between oral BP therapy for osteoporosis and the risk of breast cancer in postmenopausal women. The discrepancy between our results and the reports of such an association in observational studies might originate from an indication bias.
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsProgesterone showed the highest efficacy, followed by SSRIs/SNRIs, neuroleptic agents, and tibolone, while phytoestrogen and other types of drugs showed no efficacy advantages. There is a significant association between the baseline of hot flashes and drug efficacy, while there was no significant difference between breast cancer patients and natural menopausal women.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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