Multicenter Evaluation of a New Electrochemiluminescence Immunoassay for Everolimus Concentrations in Whole Blood
Conclusions: Based on these results, the Roche Elecsys everolimus ECLIA can be considered suitable for routine therapeutic drug monitoring. A positive bias was observed with respect to LC-MS/MS methods, suggesting that it may be necessary to rebaseline individual patients when switching from LC-MS/MS to the ECLIA; however, this must also be considered for any change of method for everolimus measurement.
Conclusion: Collectively, our results demonstrate that AFSCs may be a promising therapeutic treatment for ameliorating diabetes and the development of diabetic nephropathy and that the overexpression of SIRT3 in AFSCs may further increase the efficiency of stem cell-based therapy.Cell Physiol Biochem 2018;46:1508 –1524
As 4-year-0ld Elianna Grace sat in the back seat of the SUV, battling her second fever in three days, her mom flashed back to the coughing and vomiting fit the preschooler had the previous weekend — and to a niggling fear about the girl's sudden illness. Elianna had spent April 14 playing in her grandparents' […]Related:FDA cracks down on sales of Juul, other e-cigarettes to youthsInside the secret U.S. stockpile meant to save us all in a bioterror attackVeteran receives penis and scrotum transplant in surgery doctors say is a medical first
Conclusions: Mechanical circulatory support is an effective method of pulmonary hypertension treatment for patients disqualified for OHT due to high PVR. PMID: 29681957 [PubMed]
Authors: Schmalz G, Berisha L, Wendorff H, Widmer F, Marcinkowski A, Teschler H, Sommerwerck U, Haak R, Kollmar O, Ziebolz D Abstract BACKGROUND: Aim of this study was to investigate the association of the time under immunosuppression and different immunosuppressive medication on periodontal parameters and selected periodontal pathogenic bacteria of immunosuppressed patients after solid organ transplantation (SOT). MATERIAL AND METHODS: 169 Patients after SOT (lung, liver or kidney) were included and divided into subgroups according their time under (0-1, 1-3, 3-6, 6-10 and>10 years) and form of immunosuppre...
The world's first successful total penis and scrotum transplant was completed at Johns Hopkins Hospital on March 26, according to a news release issued Monday.
Medrano JAD Abstract Primary sclerosing cholangitis (PSC) is a rare idiopathic condition with immunopathogenic mechanisms where there is chronic progressive destruction of the biliary tree. Secondary sclerosing cholangitis (SSC) is clinically comparable to PSC, but is caused by specific processes which directly damage the biliary tree; examples include recurrent pancreatitis, bile duct malignancy, congenital bile duct abnormalities. A new cause of SSC has been described during or following significant critical illness associated with severe respiratory insufficiency, vasopressor requirement, shock and sepsis. This...
Abstract Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora. Adv...
Johns Hopkins University surgeons rebuilt man's entire pelvic region, transplanting a penis, scrotum and part of the abdominal wall from a deceased donor after 'an unspoken injury of war.'
The first total penis and scrotum transplant has now been performed by a team of Johns Hopkins surgeons. The recipient, they say, 'is recovering well.'
Jay Crouch, seven, from Market Harborough, Leicestershire, received two new kidneys, a liver, a small intestine and a pancreas from a single donor. He spent four weeks in hospital.