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Multicenter Evaluation of a New Electrochemiluminescence Immunoassay for Everolimus Concentrations in Whole Blood

Conclusions: Based on these results, the Roche Elecsys everolimus ECLIA can be considered suitable for routine therapeutic drug monitoring. A positive bias was observed with respect to LC-MS/MS methods, suggesting that it may be necessary to rebaseline individual patients when switching from LC-MS/MS to the ECLIA; however, this must also be considered for any change of method for everolimus measurement.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research

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Purpose: The transition from pediatric to adult medical services is an important time for an adolescent with a renal transplant. Failure to properly transition can lead to medical non-adherence and subsequent loss of graft and/or return to dialysis.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
Purpose: Adolescent and young adult (AYA) kidney transplant (KT) recipients experience high rates of premature allograft loss. The healthcare transition (HCT) process is considered contributory. Yet, most AYA with KT navigate transition to adult care successfully, generating a critical need to identify protective factors associated with stable transition. Resilience is a learned and dynamic process with known positive impact on health outcomes. The purpose of this study is to explore the novel role of resilience as a protective factor in securing stable HCT in AYA with KT.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
Conclusion This first description of CYP3A4*20 null genotype in liver-transplanted patients, supports the relevance of CYP3A genotyping in tacrolimus therapy.
Source: Pharmacogenetics and Genomics - Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Conclusions: Bladder urothelial neoplasms following renal transplant is associated with a trend toward worst prognosis. Early aggressive treatments, such as early radical cystectomy, might be advisable to reduce cancer-specific deaths.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
Conclusion: Our findings suggest a potential negative impact of fresh RBC transfusion on the survival of patients undergoing liver transplantation.
Source: Annals of Surgery - Category: Surgery Tags: Original Articles Source Type: research
Purpose of review Finding the right immunosuppressive approach for the individual transplant patient is of utmost importance. In truth, a ‘one size fits all’ does not exist, and as patients differ, so should therapeutic suppression of the immune system be individualized. For over three decades, biologics have been a central component of transplant immunosuppression. Our growing knowledge of immunological processes combined with biotechnological advances is leading to promising new therapeutic concepts and possibilities including novel biologics. Use of biologics may be appropriate at various phases of kidney ...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: MECHANISMS OF REJECTION: Edited by Reza Abdi Source Type: research
No abstract available
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: TOLERANCE INDUCTION: Edited by Maria-Luisa Alegre Source Type: research
Purpose of review Micro-RNAs (miRNAs) are highly conserved small RNA molecules that have selective gene-regulatory functions. This posttranscriptional regulation by miRNAs is critical for many immunological processes. Many developments in establishing the biological role of miRNAs in solid organ transplantation have been generated in the last decade. Discoveries of immune regulation by miRNAs, resulting in graft prolongation and transplant tolerance, are rapidly advancing and are the subject of this review. Recent findings Many elegant experimental studies have revealed intriguing associations between transplant toler...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: TOLERANCE INDUCTION: Edited by Maria-Luisa Alegre Source Type: research
Purpose of review To evaluate role of the lymph node in immune regulation and tolerance in transplantation and recent advances in the delivery of antigen and immune modulatory signals to the lymph node. Recent findings Lymph nodes are a primary site of immune cell priming, activation, and modulation, and changes within the lymph node microenvironment have the potential to induce specific regulation, suppression, and potentially tolerance. Antigen enters the lymph node either from tissues via lymphatics, from blood via high endothelial venules, or directly via injection. Here we review different techniques and material...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: TOLERANCE INDUCTION: Edited by Maria-Luisa Alegre Source Type: research
Purpose of review Herein our focus will be to revisit peripheral tolerance mechanisms and in particular ‘active’ or ‘dominant’ tolerance as originally defined and mediated by regulatory CD4+FoxP3+ T lymphocytes (Treg) and also T-cell anergy that appears as a major mainstay to support long-term allograft survival. Recent findings It is at the same time interesting and rewarding that the tool that recently guided our efforts along this path is the in-vivo use of CD3 antibody, the first monoclonal introduced in the clinic (Orthoclone OKT3) about 35 years ago to treat and prevent rejection of renal...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: TOLERANCE INDUCTION: Edited by Maria-Luisa Alegre Source Type: research
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