Neurogenetic Approaches to Stress and Fear in Humans as Pathophysiological Mechanisms for Posttraumatic Stress Disorder

We report that genes related to the regulation of the hypothalamus-pituitary-adrenal axis as well as genes that modulate serotonergic, dopaminergic, and neuropeptergic functions or plasticity, play a role in this context. The strong overlap of the genetic targets involved in stress and fear learning suggests that a dimensional and mechanistic model of the development of PTSD based on these constructs is promising.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research