In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase.

In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase. Cell Mol Biol (Noisy-le-grand). 2017 Dec 30;63(12):25-28 Authors: Kaya MO, Gül GÇK, Kurtuluş F Abstract Xanthine Oxidase (XO) is related with different diseases such as vascular, gout, nephropathy and renal stone diseases that are relevant to high uric acid levels and oxidative stress. Some common natural inhibitors of xanthine oxidase are known as rosmarinic acid and apigenin. With this study, we aimed to determine inhibitory effects of originally synthesized new generation transition metal vanadates on Xanthine Oxidase (XO) from bovine milk. Because, Xanthine oxidase inhibitors are typically used in the treatment of gout and nephropathy and renal stone diseases linked to hyperuricaemia. We found considerable IC50 constants for inhibition of XO. Among the synthesized compounds, Cu‒V‒O was found to be the most active (IC50 = 7.119 mM) for inhibition of XO. PMID: 29307337 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Authors: Palazzuoli A, Hashemi H, Jameson LC, McCullough PA Abstract Uric acid (UA), the metabolic mediator of gout and urate renal stones, is associated with increased cardiovascular risk burden. Hyperuricemia is a common metabolic disorder, and interaction among UA and cardiovascular diseases has been clearly described. Several illnesses, including hypertension, myocardial infarction, metabolic syndrome, and heart failure, are related to increases in UA levels. In this article, we discuss the pathophysiology of hyperuricemia and describe the biologic plausibility of this metabolite's participation in the pathogen...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
Kelley-Seegmiller syndrome (KSS) is a disorder that occurs when there is a partial deficiency of the enzyme hypoxanthine guanine phosphoribosyl transferase. It is involved in the metabolism of purines, clinically manifesting as hyperuricemia, hyperuricosuria, gout arthritis, and urolithiasis. The aim of this article is to present the case of a 33-year-old male with KSS, with left ureteral colic, and a 5-mm, 323-HU ureteral calculi, successfully managed with conservative management. It is critical to recognize that most urologists are not familiar with this inborn metabolic error and 75% of these patients will be affected b...
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
Abstract The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum uric acid. One of them is transporters which are responsible for the debouchment of uric acid within blood. The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
Conclusions: HSV-2 seropositivity and oral HPV DNA positivity were associated with self-reported arthritis and not with comparator outcomes, after adjustment for multiple potential confounders. These findings should be confirmed in longitudinal studies. PMID: 30364066 [PubMed]
Source: International Journal of Rheumatology - Category: Rheumatology Tags: Int J Rheumatol Source Type: research
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Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
In conclusion, the association between allopurinol and teratogenicity appears to be weak and limited to two reports with uncertain causality. However, the available data are insufficient to make a certain judgement, and as allopurinol treatment evolves, report and prospective follow-up of all exposed infants (i.e. deviant and normal cases) should be encouraged.
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Abstract Uric acid (UA) is a metabolite of purine degradation and is involved in gout flairs and kidney stones formation. GLUT9 (SLC2A9) was previously shown to be a urate transporter in vitro. In vivo, humans carrying GLUT9 loss-of-function mutations have familial renal hypouricemia type 2, a condition characterized by hypouricemia, UA renal wasting associated with kidney stones, and an increased propensity to acute renal failure during strenuous exercise. Mice carrying a deletion of GLUT9 in the whole body are hyperuricemic and display a severe nephropathy due to intratubular uric acid precipitation. However, th...
Source: Pflugers Archiv : European Journal of Physiology - Category: Physiology Authors: Tags: Pflugers Arch Source Type: research
Dual energy CT has been possible since last decade and has demonstrated considerable advantages in clinical diagnosis. DECT is achieved by ways that are unique to different CT platforms. DECT is considered as a first step towards achieving true “Spectral CT”. There are numerous applications including improved lesion detection and characterization, artifacts reduction and possible quantification of CT images. Advanced applications such as kidney stone classifications, gout detection, automatic bone removal, virtual non-contrast enhanced images and many others are routinely used clinically.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Source Type: research
People who have gout, kidney stones, or a similar disorder can often benefit from following a low-purine diet. Purine is a naturally occurring substance, and too much can lead to a buildup of uric acid. In this article, learn which foods to eat and which to avoid to reduce levels of purine in the body.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Urology / Nephrology Source Type: news
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Richard J. Johnson, George L. Bakris, Claudio Borghi, Michel B. Chonchol, David Feldman, Miguel A. Lanaspa, Tony R. Merriman, Orson W. Moe, David B. Mount, Laura Gabriella Sanchez Lozada, Eli Stahl, Daniel E. Weiner, Glenn M. ChertowUrate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome, but its relationship to kidney disease, cardiovascular disease, and diabetes remains controversial. A scientific workshop organized by the National Kidney Foundation was held in September 2016 to review c...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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