Frequency of Desaturation and Association With Hemodynamic Adverse Events During Tracheal Intubations in PICUs

Objectives: Oxygen desaturation during tracheal intubation is known to be associated with adverse ICU outcomes in critically ill children. We aimed to determine the occurrence and severity of desaturation during tracheal intubations and the association with adverse hemodynamic tracheal intubation–associated events. Design: Retrospective cohort study as a part of the National Emergency Airway Registry for Children Network’s quality improvement project from January 2012 to December 2014. Setting: International PICUs. Patients: Critically ill children younger than 18 years undergoing primary tracheal intubations in the ICUs. Interventions: tracheal intubation processes of care and outcomes were prospectively collected using standardized operational definitions. We defined moderate desaturation as oxygen saturation less than 80% and severe desaturation as oxygen saturation less than 70% during tracheal intubation procedures in children with initial oxygen saturation greater than 90% after preoxygenation. Adverse hemodynamic tracheal intubation–associated event was defined as cardiac arrests, hypo or hypertension requiring intervention, and dysrhythmia. Measurements and Main Results: A total of 5,498 primary tracheal intubations from 31 ICUs were reported. Moderate desaturation was observed in 19.3% associated with adverse hemodynamic tracheal intubation–associated events (9.8% among children with moderate desaturation vs 4.4% without desat...
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

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Publication date: October 2018Source: Pregnancy Hypertension, Volume 14Author(s): Cheng-Qiu Lu, Jie Lin, Lin Yuan, Jian-Guo Zhou, Kun Liang, Qing-Hua Zhong, Jin-Hua Huang, Li-Ping Xu, Hui Wu, Zhi Zheng, Li-Li Ping, Yi Sun, Zhan-Kui Li, Ling Liu, Qin Lyu, Chao ChenAbstractObjectiveTo identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks.Study designProspectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
In conclusion, it remains unclear whether AD is a risk factor for metabolic syndrome and its components. However, data indicate that central obesity is associated with AD and that the association is stronger for women than men.Dermatology
Source: Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 15 August 2018Source: Journal of Organometallic ChemistryAuthor(s): Jili Li, Jinlong Zhang, Qiuping Zhang, Zhongjie Bai, Quanyi Zhao, Zhen Wang, Yonglin Chen, Bin LiuAbstractIn this paper, three kinds of hybrid carbonyl cobalt CO-releasing molecules (CORMs), RCOOCH2C2H[Co2(CO)6] (R = NSAIDs-COOH, 1–11; R = celecoxib derivative-COOH, 15), RSO2(R’) CH2C2H[Co2(CO)6] (R = celecoxib, 12; R = nimesulide, 13) and ROCH2C2H[Co2(CO)6] (R = ferulic acid etheyl ester, 14), were synthesized and characterized by IR, NMR and HRMS. The crystal structures of complexes 9, 11...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
ConclusionsThe relief of key OAB symptoms produced by mirabegron 50 mg is significantly better than placebo, and similar to a range of common antimuscarinics, with the benefit of significantly fewer bothersome anticholinergic side effects such as dry mouth. Combination treatment of solifenacin 5 mg plus mirabegron 25 or 50 mg appears to provide an efficacy benefit compared with mirabegron 50 mg, with the expected side effects of individual antimuscarinics.Patient summaryThis study assessed the efficacy and tolerability of different drug treatments for OAB. Mirabegron 50 mg was as effective as antim...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Hypertension is very common, and it's a major cardiovascular risk factor. An innovative 'three in one' pill may help treat it more easily and effectively.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Hypertension Source Type: news
Conditions:   Hyperlipidemias;   Hypertension Interventions:   Drug: AD-2071 10/20mg;   Drug: AD-2072 80/5mg;   Drug: AD-2071 10/20mg + AD2072 80/5mg Sponsor:   Addpharma Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
CONCLUSION: Members of the ABC have varied amounts of research productivity. We identified a group of experienced investigators to engage in efforts aimed at recruiting/enrolling underrepresented racial and ethnic populations in clinical trials of cardiovascular disease. PMID: 30100090 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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