Exposure assessment of process-related contaminants in food by biomarker monitoring.

Exposure assessment of process-related contaminants in food by biomarker monitoring.
Arch Toxicol. 2018 Jan 04;:
Authors: Rietjens IMCM, Dussort P, Günther H, Hanlon P, Honda H, Mally A, O'Hagan S, Scholz G, Seidel A, Swenberg J, Teeguarden J, Eisenbrand G
Abstract
Exposure assessment is a fundamental part of the risk assessment paradigm, but can often present a number of challenges and uncertainties. This is especially the case for process contaminants formed during the processing, e.g. heating of food, since they are in part highly reactive and/or volatile, thus making exposure assessment by analysing contents in food unreliable. New approaches are therefore required to accurately assess consumer exposure and thus better inform the risk assessment. Such novel approaches may include the use of biomarkers, physiologically based kinetic (PBK) modelling-facilitated reverse dosimetry, and/or duplicate diet studies. This review focuses on the state of the art with respect to the use of biomarkers of exposure for the process contaminants acrylamide, 3-MCPD esters, glycidyl esters, furan and acrolein. From the overview presented, it becomes clear that the field of assessing human exposure to process-related contaminants in food by biomarker monitoring is promising and strongly developing. The current state of the art as well as the existing data gaps and challenges for the future were defined. They include (1) using PBK modelling and dupl...

Source: Archives of Toxicology - January 4, 2018 Category: Toxicology Authors: Rietjens IMCM, Dussort P, Günther H, Hanlon P, Honda H, Mally A, O'Hagan S, Scholz G, Seidel A, Swenberg J, Teeguarden J, Eisenbrand G Tags: Arch Toxicol Source Type: research