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Scientists advance stem cell therapy for a leading cause of blindness

Researchers made advances toward creating stem cell-derived retinal cells used to treat a leading cause of blindness.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Dry age-related macular degeneration is an all too common, untreatable disease that eventually results in blindness. It is caused by the retinal pigment epithelium (RPE), a layer of cells above the retina that supplies it with nutrients, becomin...
Source: Medgadget - Category: Medical Devices Authors: Tags: Ophthalmology Source Type: blogs
This studycounters that notion, and the findings may suggest that many senior citizens remain more cognitively and emotionally intact than commonly believed. "We found that older people have similar ability to make thousands of hippocampal new neurons from progenitor cells as younger people do. We also found equivalent volumes of the hippocampus (a brain structure used for emotion and cognition) across ages. Nevertheless, older individuals had less vascularization and maybe less ability of new neurons to make connections. It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive fun...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
THURSDAY, April 5, 2018 -- A composite implant, termed the California Project to Cure Blindness-Retinal Pigment Epithelium 1 (CPCB-RPE1), which consists of a polarized monolayer of human embryonic stem cell-derived RPE (hESC-RPE) on an ultrathin...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
For many of the 10 million Americans who are losing their vision to a thievish eye condition with no treatment, help may be on its way.In a very early clinical trial, researchers have implanted a stem cell “patch” to repair failing retinal cells in four patients with a condition called “dry” macular...
Source: Los Angeles Times - Science - Category: Science Authors: Source Type: news
We report an interim analysis of the phase 1 cohort consisting of five subjects. Four of five subjects enrolled in the study successfully received the composite implant. In all implanted subjects, optical coherence tomography imaging showed changes consistent with hESC-RPE and host photoreceptor integration. None of the implanted eyes showed progression of vision loss, one eye improved by 17 letters and two eyes demonstrated improved fixation. The concurrent structural and functional findings suggest that CPCB-RPE1 may improve visual function, at least in the short term, in some patients with severe vision loss from advanced NNAMD.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Abstract PURPOSE: To systematically review the published literature on outcomes of Boston keratoprosthesis type 1 for the treatment of limbal stem cell deficiency secondary to severe chemical corneal injury. METHODS: Literature searches were conducted in MEDLINE (Ovid), Embase, Web of Science, and the Cochrane Central Register. The main outcome measures assessed were the proportion of eyes with best-corrected visual acuity (BCVA) ≥ 20/200 and the proportion retaining their original keratoprosthesis, both at the last recorded visit. RESULTS: We identified 9 reports in which outcomes of Boston kerat...
Source: The Ocular Surface - Category: Opthalmology Authors: Tags: Ocul Surf Source Type: research
Publication date: Available online 22 March 2018 Source:Progress in Retinal and Eye Research Author(s): Erin R. Burnight, Joseph C. Giacalone, Jessica A. Cooke, Jessica R. Thompson, Laura R. Bohrer, Kathleen R. Chirco, Arlene V. Drack, John H. Fingert, Kristan S. Worthington, Luke A. Wiley, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker Gene correction is a valuable strategy for treating inherited retinal degenerative diseases, a major cause of irreversible blindness worldwide. Single gene defects cause the majority of these retinal dystrophies. Gene augmentation holds great promise if delivered early in the course of ...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Doctors in the UK say they have taken an important step towards treating a common form of blindness – wet age-related macular degeneration (AMD).WebMD Health News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ophthalmology News Source Type: news
Stem cell therapy restored some vision to two patients with a common cause of blindness called age-related macular degeneration, U.K. doctors say. Stem cells from a human embryo were converted into a patch of a specific type of eye cell and grown...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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