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Scientists advance stem cell therapy for a leading cause of blindness

Researchers made advances toward creating stem cell-derived retinal cells used to treat a leading cause of blindness.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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Source: Stem Cells - Category: Stem Cells Authors: Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
A man in a flagship stem cell trial for age-related macular degeneration has swelling in his eye, but the cause is probably surgery – not stem cells
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
This article is protected by copyright. All rights reserved.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Regenerative Medicine Source Type: research
Publication date: Available online 4 January 2018 Source:Stem Cell Reports Author(s): Paul V. Waldron, Fabiana Di Marco, Kamil Kruczek, Joana Ribeiro, Anna B. Graca, Claire Hippert, Nozie D. Aghaizu, Aikaterini A. Kalargyrou, Amanda C. Barber, Guilia Grimaldi, Yanai Duran, Samuel J.I. Blackford, Magdalena Kloc, Debbie Goh, Eduardo Zabala Aldunate, Robert D. Sampson, James W.B. Bainbridge, Alexander J. Smith, Anai Gonzalez-Cordero, Jane C. Sowden, Robin R. Ali, Rachael A. Pearson Human vision relies heavily upon cone photoreceptors, and their loss results in permanent visual impairment. Transplantation of healthy photorece...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Abstract A major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retinitis Pigmentosa or age-related macular degeneration. The lack of effective therapies to stop photoreceptor loss together with the absence of significant intrinsic regeneration in the human retina converts such degenerative diseases into permanent conditions that are currently irreversible. Cell replacement by means of photoreceptor transplantation has been propos...
Source: Developmental Biology - Category: Biology Authors: Tags: Dev Biol Source Type: research
(NIH/National Eye Institute) Scientists at the National Eye Institute report that tiny tube-like protrusions called primary cilia on cells of the retinal pigment epithelium (RPE) -- a layer of cells in the back of the eye -- are essential for the survival of the retina's light-sensing photoreceptors. The discovery has advanced efforts to make stem cell-derived RPE for transplantation into patients with geographic atrophy, otherwise known as dry age-related macular degeneration (AMD), a leading cause of blindness in the US.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
This article discusses the challenges and outcomes of cataract surgery in complex cases targeting eyes with ocular surface diseases like Stevens–Johnson syndrome, ocular cicatricial pemphigoid, Mooren's ulcer, vernal keratoconjunctivitis and limbal stem cell deficiency. Recent findings Ocular surface diseases are commonly associated with corneal scarring and vascularization, conjunctival inflammation, symblepharon and forniceal shortening. Any surgical intervention in a hostile ocular surface environment may worsen the disease, which may result in visual deterioration. In recent past, with the use of immunosuppres...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: CATARACT SURGERY AND LENS IMPLANTATION: Edited by Natalie A. Afshari Source Type: research
Retinal degeneration (RD) is a leading cause of irreversible blindness, affecting millions of people worldwide. Stem cell transplantation has been considered a promising therapy for retinal degenerative diseas...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Publication date: 1 April 2018 Source:Materials Science and Engineering: C, Volume 85 Author(s): Laura Koivusalo, Jennika Karvinen, Eetu Sorsa, Ilari Jönkkäri, Jari Väliaho, Pasi Kallio, Tanja Ilmarinen, Susanna Miettinen, Heli Skottman, Minna Kellomäki Corneal blindness is a worldwide problem, plagued by insufficient amount of high-quality donor tissue. Cell therapy using human adipose stem cells (hASCs) has risen as an alternative to regenerate damaged corneal stromal tissue, the main structural and refractive layer of the cornea. Herein we propose a method to deliver hASCs into corneal defects in hy...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, we asked people in an open-ended way about their desire for longer life: Would you like to have more time? What age would you like to become? This was something more specific than asking about a preference for survival without reference to any length of time; about one's plans for the future; or whether people see the future as open or limited, as in studies of future time perspective. Our attempt was to discover whether there were preferred temporal spans with which older adults framed their futures and plans. The two-question series about extra years and desired age ("How old would you like to ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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