MicroRNA-296 targets specificity protein 1 to suppress cell proliferation and invasion in cervical cancer.

This study aims to detect miR-296 expression in cervical cancer and evaluate its roles and underlying mechanisms in cervical cancer. This study demonstrated that miR-296 was significantly downregulated in cervical cancer tissues and cell lines. Restoring the expression of miR-296 inhibited the proliferation and invasion of cervical cancer cells. Moreover, miR-296 directly targeted the 3'-untranslated regions of specificity protein 1 (SP1) and decreased its endogenous expression at both mRNA and protein levels. Similar to induced miR-296 expression, SP1 knockdown suppressed the proliferation and invasion of cervical cancer cells. Besides, resumption expression of SP1 rescued the tumour-suppressing roles of miR-296 in cervical cancer. These results indicated that miR-296 may act as a tumour suppressor in cervical cancer by directly targeting SP1. Therefore, SP1 may be developed as a therapeutic target for treatment of patients with this malignancy. PMID: 29241478 [PubMed - as supplied by publisher]
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research