A vicious interplay between genetic and environmental insults in the etiology of blood cancers

• Epigenetic (embryos) and genetic (aging) mechanisms generate multiple HSC clones• Aging reduces the number of active HSC clones• Old HSC clones have lower self-renewal and skewed myeloid differentiation potential• Environmental and genetic insults can cooperately initiate blood cancer• E nvironmental insults may provide proliferative advantages to malignant HSCs
Source: Experimental Hematology - Category: Hematology Authors: Tags: Perspective Source Type: research