The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine

• Several studies about the antinociceptive effects of ketamine were made.• The CB1 cannabinoid receptor and the anandamide participation in ketamine mechanism was tested.• Ketamine induced peripheral antinociception by anandamide release.• ketamine as a peripheral analgesic for inflammatory pain.

Source: The Journal of Pain - December 13, 2017 Category: Materials Science Authors: Renata C.M. Ferreira, Marina G.M. Castor, Fabiana Piscitelli, Vincenzo Di Marzo, Igor D.G. Duarte, Thiago R.L. Romero Tags: Original Report Source Type: research