FDA Approves Amgen's Repatha (evolocumab) to Prevent Heart Attack and Stroke

THOUSAND OAKS, Calif., Dec. 1, 2017 /PRNewswire/ -- Amgen (NASDAQ: AMGN) today announced that following priority review of its supplemental Biologics License Application, the U.S. Food and Drug Administration (FDA) approved Repatha (evolocumab) as...
Source: Drugs.com - New Drug Approvals - Category: Drugs & Pharmacology Source Type: news

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ić M Abstract Cardiovascular diseases represent one of the most notable health problems of the modern civilization. Stroke and heart attack often lead to lethal outcome; essential problem underneath being thrombus formation. Prophylactic approaches include acetylsalicylic acid and clopidogrel therapy on the level of primary hemostasis, i.e., primary clot formation. In the last five years, in the USA, health care expenses related to cardiovascular diseases have increased 50 %, to over 350 billion dollars. Thus, application of plant species and medicinal plants rich in polyphenols in prevention of thrombus formatio...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
BEST supplements for cholesterol: Having high levels of cholesterol is extremely dangerous as it puts a person at risk of serious medical conditions including heart attack or stroke. Taking a certain supplement, however, could help lower your cholesterol.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Lytvyn Y, Bjornstad P, van Raalte DH, Heerspink HL, Cherney DZI Abstract Diabetic kidney disease remains the most common cause of end-stage kidney disease in the world. Despite reductions in incidence rates of myocardial infarction and stroke in people with diabetes over the past 3 decades, the risk of diabetic kidney disease has remained unchanged, and may even be increasing in younger individuals afflicted with this disease. Accordingly, changes in public health policy have to be implemented to address the root causes of diabetic kidney disease, including the rise of obesity and diabetes, in addition to ...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
ConclusionThe present meta-analysis suggests that consuming curcumin/turmeric may improve SBP when administered in long durations. However, more studies are needed to confirm these results.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
‘Chronotherapy’ benefits of bedtime doses discovered in huge trialTaking blood pressure medication at bedtime rather than on waking halves the risk of events such as heart attack and stroke, a major study has revealed.Experts say the findings could potentially transform the way such medications are prescribed, but questions remain, not least why taking the medication at night has such a profound effect.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Heart disease Society Heart attack Medical research Science Spain Stroke Source Type: news
ConclusionsThe study is designed to identify a TxA dose with maximal efficacy and minimal complications. We hypothesize that the high dose has superior efficacy and non-inferior safety to the low dose.
Source: American Heart Journal - Category: Cardiology Source Type: research
harya Hypertension (HT) is an extreme increment in blood pressure that can prompt a stroke, kidney disease, and heart attack. HT does not show any symptoms at the early stage, but can lead to various cardiovascular diseases. Hence, it is essential to identify it at the beginning stages. It is tedious to analyze electrocardiogram (ECG) signals visually due to their low amplitude and small bandwidth. Hence, to avoid possible human errors in the diagnosis of HT patients, an automated ECG-based system is developed. This paper proposes the computerized segregation of low-risk hypertension (LRHT) and high-risk hypertension (...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Women who go through menopause earlier in life may be more likely to have a heart attack or stroke before they reach age 60 than their counterparts who go through menopause later on, a recent study suggests.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
ConclusionsLinagliptin showed cardiovascular and renal safety in Asian patients with T2DM and established CVD with albuminuria and/or kidney disease.
Source: Diabetology International - Category: Endocrinology Source Type: research
CONCLUSIONS: Bisphosphonate therapy may reduce fracture and bone pain after kidney transplantation, however low certainty in the evidence indicates it is possible that treatment may make little or no difference. It is uncertain whether bisphosphonate therapy or other bone treatments prevent other skeletal complications after kidney transplantation, including spinal deformity or avascular bone necrosis. The effects of bone treatment for children and adolescents after kidney transplantation are very uncertain. PMID: 31637698 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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