Flexible sigmoidoscopy screening reduces colorectal cancer incidence, rate of death

(The JAMA Network Journals) Among about 100,000 study participants, screening with flexible sigmoidoscopy resulted in a reduced incidence and rate of death of colorectal cancer, compared to no screening, according to a study in the Aug. 13 issue of JAMA.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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ConclusionsScreening colonoscopy was associated with greater reductions in CRC mortality than screening sigmoidoscopy, and with a greater reduction in the distal than the proximal colon. These results provide additional information on the relative benefits of screening for CRC with sigmoidoscopy and colonoscopy.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
This study included PWH and demographically matched persons without HIV who were aged 50–75 years during 2005–2016 and had no previous CRC screening. We evaluated time to first CRC screening (fecal test, sigmoidoscopy, or colonoscopy). We also assessed detection of adenoma and CRC with sigmoidoscopy or colonoscopy by HIV status, accounting for CRC risk factors including sex, age, race/ethnicity, number of outpatient visits, smoking, body mass index, type-2 diabetes, and inflammatory bowel disease. Among PWH, we evaluated whether CD4 count (
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Epidemiology Source Type: research
CONCLUSION: WW and LE were comparable in terms of 5-year OS and RFS. In the LE group, salvage treatment was performed much less among indicated patients. Therefore, methods to improve the oncologic outcomes of patients indicated for salvage treatment should be considered before local excision. PMID: 31113171 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Condition:   Colorectal Cancer Interventions:   Other: Right time eating;   Other: Delayed time eating;   Procedure: Sigmoidoscopy;   Procedure: Optional 24h circadian assessment in the Biological Rhythms lab;   Other: Alcohol Sponsor:   Rush University Medical Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 1 April 2019Source: Preventive MedicineAuthor(s): Chen Chen, Christian Stock, Lina Jansen, Jenny Chang-Claude, Michael Hoffmeister, Hermann BrennerAbstractAn increasing number of countries have recently introduced colorectal cancer (CRC) screening programs. Typically, one specific screening exam, such as fecal occult blood test (FOBT) or flexible sigmoidoscopy, is offered as a primary screening test. We aimed to assess trends in FOBT and colonoscopy use in Germany following the introduction of the offer of screening colonoscopy as an alternative to FOBT in 2002. We used data from 4052 con...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Colorectal cancer (CRC) has a significant impact on public health owing to its high incidence, morbidity, and mortality.1 It is the third most common cancer in men and second in women, and in most countries the second leading cause of cancer-related death.1,2 The early detection and removal of precursor cancer lesions decreases CRC incidence and mortality. CRC screening has, therefore, been implemented in various countries worldwide.3 The selected modality varies per country or region and differs from primary colonoscopy, sigmoidoscopy to noninvasive testing, in particular by means of a fecal immunochemical test (FIT).
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research
Colorectal cancer (CRC) has a significant impact on public health owing to its high incidence, morbidity, and mortality.1 It is the third most common cancer in men and second in women, and in most countries the second leading cause of cancer-related death.1,2 The early detection and removal of precursor cancer lesions decreases CRC incidence and mortality. CRC screening has, therefore, been implemented in various countries worldwide.3 The selected modality varies per country or region and differs from primary colonoscopy, sigmoidoscopy to noninvasive testing, in particular by means of a fecal immunochemical test (FIT).
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research
CONCLUSIONS: Sole CIBH without anemia/abdominal mass yields a 2.5% colorectal malignancy rate from 2-week wait referrals. Those with PLS had a 0.17% yield of proximal tumors. A straight-to-test FS in this low risk group would be clinically effective with potential annual savings of more than £50 000. PMID: 30898041 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
We examined Blacks, Asians, and Hispanics relative to Whites, and Females relative to Males (with race or ethnicity combined). We examined each state separately for evidence of disparities within states, to avoid confounding by geographic disparities. We expected that the net effect o f the policy changes and the targeted interventions over the decade would be to increase CRC screening by endoscopy, reducing disparities. We saw improvements over time (reduced disparities relative to Whites) for Blacks and Hispanics residing in several states, and improvements over time for Female s relative to Males in many states. For the...
Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
CONCLUSIONS: There is a higher than expected risk that if a cancer is diagnosed in a patient presenting with either an isolated change in bowel habit or a combination of change in bowel habit with rectal bleeding, the cancer may be right sided. PMID: 30855983 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
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