Regulation of host-pathogen interactions via the post-transcriptional Csr/Rsm system.

Regulation of host-pathogen interactions via the post-transcriptional Csr/Rsm system.
Curr Opin Microbiol. 2017 Dec 02;41:58-67
Authors: Kusmierek M, Dersch P
Abstract
A successful colonization of specific hosts requires a rapid and efficient adaptation of the virulence-relevant gene expression program by bacterial pathogens. An important element in this endeavor is the Csr/Rsm system. This multi-component, post-transcriptional control system forms a central hub within complex regulatory networks and coordinately adjusts virulence properties with metabolic and physiological attributes of the pathogen. A key function is elicited by the RNA-binding protein CsrA/RsmA. CsrA/RsmA interacts with numerous target mRNAs, many of which encode crucial virulence factors, and alters their translation, stability or elongation of transcription. Recent studies highlighted that important colonization factors, toxins, and bacterial secretion systems are under CsrA/RsmA control. CsrA/RsmA deficiency impairs host colonization and attenuates virulence, making this post-transcriptional regulator a suitable drug target. The CsrA/RsmA protein can be inactivated through sequestration by non-coding RNAs, or via binding to specific highly abundant mRNAs and interacting proteins. The wide range of interaction partners and RNA targets, as well as the overarching, interlinked genetic control circuits illustrate the complexity of this regulatory system in the diff...

Source: Current Opinion in Microbiology - December 2, 2017 Category: Microbiology Authors: Kusmierek M, Dersch P Tags: Curr Opin Microbiol Source Type: research