Lab-engineered ovaries superior to hormone drugs in animal model

(Wake Forest Baptist Medical Center) New research in rats suggests the possibility of bioengineering artificial ovaries in the lab to provide a safer, more natural hormone replacement therapy for women. A safe therapy, with the potential to improve bone and uterine health, as well as body composition, is expected to become increasing important as the population ages.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Abstract There is increasing evidence that menopause is associated with the progression and severity of non-alcoholic fatty liver disease (NAFLD). Estrogen deficiency worsens non-alcoholic steatohepatitis (NASH) in mice models with fatty liver. The prevalence of NAFLD seems to be higher in postmenopausal compared with premenopausal women. Although more data are needed, lower serum estradiol levels are associated with NASH in postmenopausal women. Apart from estrogen deficiency, relative androgen excess and decrease in sex hormone-binding protein are observed in postmenopausal women. These hormonal changes seem to ...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
CONCLUSIONS: Biallelic mutations in POLG may be associated with ovarian dysfunction. This study has improved our understanding of POLG-related genetic mutations in ovarian dysfunction, and the mode of inheritance of certain sequence variants. This information will assist genetic counseling and precision medicine in the future. PMID: 29992832 [PubMed - as supplied by publisher]
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
ConclusionsExogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations.
Source: Arab Journal of Urology - Category: Urology & Nephrology Source Type: research
Scientists at the University of Washington have shown we could target a neuron rather than estrogen levels with drugs. Hormone replacement therapy reduces hot flashes but increases stroke risk.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: June 2017Source: Best Practice &Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. CostenbaderAbstractSystemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for ...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Scientists at the University of Washington have shown we could target a neuron rather than estrogen levels with drugs. Hormone replacement therapy reduces hot flashes but increases stroke risk.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceut...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 6 June 2018Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Tarik Kirkgoz, Tulay GuranPrimary adrenal insufficiency (PAI) is a life-threatening disorder of adrenal cortex which is characterized by deficient biosynthesis of glucocorticoids, with or without deficiency in mineralocorticoids and adrenal androgens. Typical manifestations of primary adrenal insufficiency include hyperpigmentation, hypotension, hypoglycaemia, hyponatremia with or without hyperkalemia that are generally preceded by nonspecific symptoms at the onset. Recessively inherited monoge...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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