[Affinity of Luliconazole for Human Nail Derived Keratin].

In conclusion, LLCZ is considered to possess high affinity to nail keratin. LLCZ, therefore, can be retained in the nail as a reservoir and continuously desorbed at the infection site to exhibit antifungal activity against pathogenic fungi. The pharmacokinetics of LLCZ in the nail is believed to differ from that of EFCZ. As adsorption and desorption rates of the two drugs in nail keratin tended to be different between healthy volunteers and patients, further detailed study is needed. PMID: 29187718 [PubMed - in process]
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research