Survival analysis of women with breast cancer: competing risk models
This study aimed to estimate the effects of prognostic factors on breast cancer survival, such as age, staging, and extension of the tumor, using proportional hazards and competing risks models proposed by Cox and Fine-Gray, respectively. This is a retrospective cohort study, based on a population of 524 women, who were diagnosed with breast cancer in the period from 1993 to 1995 and monitored until 2011, residents in the city of Campinas, S ão Paulo, Brazil. The cutoff points for the variable of age were defined with Cox simple models. In the settings of simple and multiple Fine-Gray models, age was not significant to the presence of competing risks, neither it was in Cox models. For both models, death by breast cancer was the event o f interest. The survival functions, estimated by Kaplan-Meier, showed significant differences for deaths by breast cancer and by competing risks. Survival functions by breast cancer did not show significant differences when comparing the age groups, according to log-rank test. Cox and Fine-Gray mode ls identified the same prognostic factors that influenced in breast cancer survival.
This study demonstrates that ROS-responsive TEP NPs are effective drug carriers for efficient intracellular delivery of hydrophobic drug, PL.Graphical abstractROS-responsive thioether-bearing polymers (TEP) were synthesized and used as drug carriers for intracellular delivery of piperlongumine (PL) in cancer cells. The PL-loaded TEP nanoparticles exhibited ROS-triggered disassembly in cancer cells, leading to efficient cancer cell-specific apoptosis.
Condition: Breast Cancer Intervention: Drug: 5-FU, epirubicin and cyclophosphamide Sponsors: Henrik Lindman; Scandinavian Breast Cancer Group; Danish Breast Cancer Group; Swedish Cancer Society; Swedish Breast Cancer Association; Uppsala University Oncology Department Trust; Pharmacia Pharmaceutical Company; Swedish Breast Cancer Group Completed
Publication date: Available online 23 March 2019Source: Seminars in Cancer BiologyAuthor(s): Daniela Grimm, Johann Bauer, Petra Wise, Marcus Krüger, Ulf Simonsen, Markus Wehland, Manfred Infanger, Thomas J. CorydonAbstractCancer is a heavy burden for humans across the world with high morbidity and mortality. Transcription factors including sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) proteins are thought to be involved in the regulation of specific biological processes. The deregulation of gene expression programs can lead to cancer development. Here, we review the role of the SOX family ...
A study by the University of California, San Diego, found that allowing obese, 'post-menopausal' mice to eat only within a strict eight-hour window 'dramatically' reduced their risk of the disease.
Among the updates are expanded treatment options, including a recently approved immunotherapy regimen for locally advanced or metastatic disease.
(The Endocrine Society) Changing when you eat rather than what you eat may prove to be a dietary intervention against breast cancer, suggests a new mouse study to be presented Saturday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.
The most common cancer amongst women is breast cancer. Reports on the role of EBV, BKV, and JCV in the development of breast cancer are controversial. Hence, the aim of this study was to determine the frequenc...
ConclusionsCollectively, our results demonstrate that KIFl8A is highly expressed in LUAD. KIFl8A plays an important role in LUAD cell proliferation, but is a poor prognostic factor.
AbstractBackgroundNeurofibromatosis type 1 (NF1) is a cancer predisposing syndrome. Studies suggest that women
ConclusionThese findings emphasize the beneficial effects of supervised high-intensity exercise during chemotherapy to improve the health and to reduce societal costs associated with prolonged sick leave for patients with breast cancer several months following chemotherapy.Implications for Cancer SurvivorsThese findings provide important information with substantial positive consequences for breast cancer survivorship. High-intensity exercise programs during chemotherapy and support to maintain physical activity can be a powerful strategy to manage or prevent many of the short- and long-term adverse effects of treatment fo...