Cancer immunotherapy: Rewiring cancer cells

Nature Reviews Drug Discovery 16, 828 (2017). doi:10.1038/nrd.2017.242 Author: Anna Dart A number of factors ranging from the scarcity of tumour-specific neoantigens, tumour immunosuppression and toxicity caused by systemic delivery of immunomodulators restrict the efficiency of cancer immunotherapies. To overcome these obstacles, Nissim, Wu et al. have engineered a synthetic gene circuit enabling the production
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research