Jardiance ® (empagliflozin) to be studied for the treatment of people with chronic heart failure

Jardiance ® (empagliflozin) to be studied for the treatment of people with chronic heart failure
Source: Boehringer Ingelheim Corporate News - Category: Research Source Type: news

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Authors: Corrà U, Piepoli M, Giordano A Abstract Exercise oscillatory ventilation (EOV) is an ominous sign in heart failure due to reduced left ventricular ejection fraction (HFrEF) whatever it is represented. But EOV is detected also in normal healthy individuals and in other cardiovascular disease (CVD) patients, however, its prevalence in these is not completed clear. The aim was to describe the occurrence of EOV in healthy subjects and the overall population all CVD patients who performing symptom limited cardiopulmonary exercise testing (CPET). Healthy subjects were divided in athletes and normal subjec...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
CONCLUSION Relatively low use of technology may limit potential for health technology innovation for people of advanced age. Socioeconomic and ethnic disparities will amplify this. PMID: 32223848 [PubMed - in process]
Source: Journal of Primary Health Care - Category: Primary Care Tags: J Prim Health Care Source Type: research
Authors: Chalikias G, Kikas P, Thomaidis A, Rigopoulos P, Pistola A, Lantzouraki A, Zisimopoulos A, Tziakas D Abstract We assessed the effect of Sacubitril/Valsartan on circulating catecholamine levels in patients with HF in an observational cohort study. We included 108 consecutive HF patients attending our HF Outpatients Clinic who were eligible to Sacubitril/Valsartan according to the PARADIGM-HF inclusion and exclusion criteria. We furthermore included 58 stable HF patients under optimal medical therapy as a control group. Norepinephrine and epinephrine were measured with immunoradiometric assays at baseline, a...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Maki H, Takeda N PMID: 32224600 [PubMed - in process]
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
 No one in pharma needs to be told that COVID-19 is upending business as we know it. But in the face of this unprecedented change there is a great opportunity to adapt, improve and profit from new ways of working. And digital capabilities are the key to realising them, says Bertrand Bodson, Chief Digital Officer and Member of the Executive Board of Novartis in his keynote speech opening the eyeforpharma Virtual, a digital version of the Barcelona event, and available to delegates who can sign up for free athttps://virtual.eyeforpharma.com. Novartis is demonstrating how pharma can achieve rapid transformation...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Heart failure, ischemic heart disease, stroke may contribute to link between air pollution and dementia
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Cardiology, Family Medicine, Geriatrics, Internal Medicine, Neurology, Psychiatry, Pulmonology, Journal, Source Type: news
In the era of increased left ventricular support device (LVAD) implantation, limited data is available on outcomes in the obese population, with most available data describing elevated BMI with a cutoff of>30 kg/m2. Forest et al examined the ISHLT Mechanically Assisted Circulatory Support (IMACS) registry and found no impact in 2-year mortality in those with higher BMIs, but an increase in all adverse events describing BMI> 40 kg/m2 group. We seek to provide our experience with this population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (69) Source Type: research
The objectives of this study were to describe survival, characterize rates of adverse events (AEs) and compare survival after an AE in patients age ≥70 vs. age 50-69.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (67) Source Type: research
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