Self-Resolving sp. Colonization in a Lung Transplant Patient
Cladophialophora spp. are dematiaceous moulds that are responsible for causing a variety of human infections in both immunocompetent and immunocompromised individuals. Infections caused by Cladophialophora spp. most commonly involve the skin and soft tissue and the central nervous system (CNS). Cladophialophora sp. infections involving the skin and soft tissues are often referred to as chromoblastomycosis, a slowly developing condition that rarely disseminates and can be treated with surgical excision and/or antifungal chemotherapy.
The objective of this study was to evaluate the susceptibility of emerging fungi to fluconazole, itraconazole and amphotericin B by disk diffusion method. In 2015, 82 emerging fungi were evaluated in IPB-LACEN/RS and 13 (15.8%) were resistant: 10/52 were from superficial mycoses and 3/30 from systemic mycoses. The data from the study point to the need for permanent vigilance regarding the careful evaluation in the prescription and clinical and laboratory follow-up of patients affected by fungal infections.
Clinical and Experimental Dermatology, EarlyView.
Abstract Chromoblastomycosis is a worldwide chronic subcutaneous infection caused by dematiaceous fungi and clinically characterized by verrucous lesions. Herein, we report a rare case of chromoblastomycosis caused by Fonsecaea monophora in a 60-year-old male carpenter with a 40-year history of psoriasis from Shandong in northern China. A fungal infection coexisting with psoriasis presents a management dilemma. Our patient responded well to combined itraconazole and acitretin therapy and the lesions resolved completely after 1 month of treatment. PMID: 29785921 [PubMed - as supplied by publisher]
CONCLUSION: This combined treatment would constitute an excellent therapeutic alternative because of its efficiency, feasibility, low cost, method of administration and aesthetic result. PMID: 29779858 [PubMed - as supplied by publisher]
CONCLUSION: Infections caused by dematiaceous fungi are rare. Medullary and brain localizations are extremely rare, especially for chromoblastomycosis. Cutaneous manifestations of phaeohyphomycosis are varied; diagnosis is thus more difficult. It is therefore important, when confronted with a chronic tumor-like lesion in endemic areas, to perform a biopsy for pathology and fungal culture. While surgical excision is not always sufficient, medical treatment of these infections is not standardized, but relies on an azole, which can be associated with another antifungal agent. PMID: 29656841 [PubMed - as supplied by publisher]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
We report a very rare case of pulmonary chromomycosis caused by Scedosporium prolificans that developed after lung transplantation and was successfully treated with endobronchial topical amphotericin B instillation. The subject was a woman in her 50s with a history of bilateral lobar lung transplantation from living donors for idiopathic pulmonary hypertension. Eight years after the lung transplantation, chest radiography X-ray and computed tomography showed an abnormal shadow in the right lung.
Abstract Our in vitro studies showed that combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including Cladophialophora carrionii, C. arxii, Exophiala dermatitidis, E. spinifera, Fonsecaea monophora, F. nubica, F. pedrosoi, and Phialophora verrucosa. This combination could provide an option for treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora. PMID: 29581111 [PubMed - as supplied by publisher]
The cover image, by Liya He et al., is based on the Original Article Successful treatment of chromoblastomycosis of 10‐year duration due to Fonsecaea nubica, DOI: 10.1111/myc.12732.
by Bilin Dong, Zhongsheng Tong, Ruoyu Li, Sharon C.-A. Chen, Weihuang Liu, Wei Liu, Yao Chen, Xu Zhang, Yiqun Duan, Dongsheng Li, Liuqing ChenFonsecaea pedrosoi (F.pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection. Experimental studies in murine models have shown that the absence of CD4+ T cells impairs host defense againstF.pedrosoi infection. Clinical research has also suggested that a relatively low level of the Th1 cytokine INF- γ and inefficient ...