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Self-Resolving sp. Colonization in a Lung Transplant Patient

Cladophialophora spp. are dematiaceous moulds that are responsible for causing a variety of human infections in both immunocompetent and immunocompromised individuals. Infections caused by Cladophialophora spp. most commonly involve the skin and soft tissue and the central nervous system (CNS). Cladophialophora sp. infections involving the skin and soft tissues are often referred to as chromoblastomycosis, a slowly developing condition that rarely disseminates and can be treated with surgical excision and/or antifungal chemotherapy.
Source: Clinical Microbiology Newsletter - Category: Microbiology Authors: Tags: Case Report Source Type: news

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CONCLUSION: Infections caused by dematiaceous fungi are rare. Medullary and brain localizations are extremely rare, especially for chromoblastomycosis. Cutaneous manifestations of phaeohyphomycosis are varied; diagnosis is thus more difficult. It is therefore important, when confronted with a chronic tumor-like lesion in endemic areas, to perform a biopsy for pathology and fungal culture. While surgical excision is not always sufficient, medical treatment of these infections is not standardized, but relies on an azole, which can be associated with another antifungal agent. PMID: 29656841 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Source: JDDG - Category: Dermatology Authors: Source Type: research
We report a very rare case of pulmonary chromomycosis caused by Scedosporium prolificans that developed after lung transplantation and was successfully treated with endobronchial topical amphotericin B instillation. The subject was a woman in her 50s with a history of bilateral lobar lung transplantation from living donors for idiopathic pulmonary hypertension. Eight years after the lung transplantation, chest radiography X-ray and computed tomography showed an abnormal shadow in the right lung.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Tags: Original Contributions: Case Reports Source Type: research
Abstract Our in vitro studies showed that combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including Cladophialophora carrionii, C. arxii, Exophiala dermatitidis, E. spinifera, Fonsecaea monophora, F. nubica, F. pedrosoi, and Phialophora verrucosa. This combination could provide an option for treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora. PMID: 29581111 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
The cover image, by Liya He et al., is based on the Original Article Successful treatment of chromoblastomycosis of 10‐year duration due to Fonsecaea nubica, DOI: 10.1111/myc.12732.
Source: Mycoses - Category: Research Tags: COVER IMAGE Source Type: research
by Bilin Dong, Zhongsheng Tong, Ruoyu Li, Sharon C.-A. Chen, Weihuang Liu, Wei Liu, Yao Chen, Xu Zhang, Yiqun Duan, Dongsheng Li, Liuqing ChenFonsecaea pedrosoi (F.pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection. Experimental studies in murine models have shown that the absence of CD4+ T cells impairs host defense againstF.pedrosoi infection. Clinical research has also suggested that a relatively low level of the Th1 cytokine INF- γ and inefficient ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Image Correspondence Source Type: research
Publication date: Available online 2 January 2018 Source:Microbiological Research Author(s): Camille Silva Florencio, Fabiana Alves Silva Brandão, Marcus de Mello Teixeira, Anamélia Lorenzetti Bocca, Maria Sueli S. Felipe, Vânia Aparecida Vicente, Larissa Fernandes Fonsecaea pedrosoi, a melanized fungal pathogen that causes Chromoblastomycosis, a human disease with a worldwide distribution. Biolistic is a widely used technique for direct delivery of genetic material into intact cells by particles bombardment. Another well-established transformation method is Agrobacterium-mediated transformation (ATMT)...
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Publication date: Available online 13 December 2017 Source:Fungal Biology Author(s): Mirelle Garcia Silva-Bailão, Kassyo Lobato Potenciano da Silva, Laura Raniere Borges dos Anjos, Patrícia de Souza Lima, Marcus de Melo Teixeira, Célia Maria de Almeida Soares, Alexandre Melo Bailão Black fungi comprise a diverse group of melanized microorganisms that can be found in a variety of environments, fact that make some of them considered extremophiles. Many species are able to adapt and grow in humans, being responsible for infections that range from mild cutaneous injuries to fatal brain diseases in ...
Source: Fungal Biology - Category: Biology Source Type: research
Publication date: Available online 8 December 2017 Source:Medical Mycology Case Reports Author(s): Marcelo Label, Luciana C. Karayan, Sybren De Hoog, Javier Afeltra, Togo Bustamante, Roxana G. Vitale Chromoblastomycosis is a mutilating infection of the skin and subcutaneous tissues caused by melanized fungi belonging to the order Chaetothyriales. Proven cases of the main agent, Fonsecaea pedrosoi are mainly limited to (sub)tropical, humid climates of Latin and Central America and the Caribbean. Fonsecaea monophora has a global distribution along the equator. Cases outside the (sub)tropics have thus far mostly been conside...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
More News: Chemotherapy | Chromoblastomycosis | Lung Transplant | Microbiology | Skin | Transplant Surgery | Transplants