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Salivary α‐amylase as a marker of stress reduction in individuals with intellectual disability and autism in response to occupational and music therapy

ConclusionsNot only do these results confirm the stress‐reducing nature of two types of multisensory therapy, but they support the use of sAA as a potential tool for evaluating stress levels in individuals with intellectual disability and autism spectrum disorder, providing an important physiological lens that may guide strategies in clinical and non‐clinical care for individuals with disabilities.
Source: Journal of Intellectual Disability Research - Category: Disability Authors: Tags: Brief Report Source Type: research

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Authors: Curatolo P, Moavero R, van Scheppingen J, Aronica E Abstract INTRODUCTION: The mammalian target of rapamycin (mTOR) pathway has emerged as a key player for proper neural network development, and it is involved in epileptogenesis triggered by both genetic or acquired factors. Areas covered. The robust mTOR signaling deregulation observed in a large spectrum of epileptogenic developmental pathologies, such as focal cortical dysplasias and tuberous sclerosis complex (TSC), has been linked to germline and somatic mutations in mTOR pathway regulatory genes, increasing the spectrum of "mTORopathies". The ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Abstract There is variability in the extent to which mothers are affected by the behavior problems of their children with developmental disabilities (DD). We explore whether maternal resilience functions as a protective or compensatory factor. In Studies 1 and 2, using moderated multiple regression models, we found evidence that maternal resilience functioned as a compensatory factor-having a significant independent main effect relationship with well-being outcomes in mothers of children with DD and autism spectrum disorder. However, there was no longitudinal association between resilience and maternal well-being ...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
AbstractSETD1B (SET domain containing 1B) is a component of SET1 histone methyltransferase complex, which mediates the methylation of histone H3 on lysine 4 (H3K4). Here, we describe two unrelated individuals with de novo variants inSETD1B identified by trio-based whole exome sequencing: c.5524C>T, p.(Arg1842Trp) and c.5575C>T, p.(Arg1859Cy). The two missense variants occurred at evolutionarily conserved amino acids and are located within the SET domain, which plays a pivotal role in catalyzing histone methylation. Previous studies have suggested that de novo microdeletions in the 12q24.3 region encompassingSETD1B we...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
This study aims to explore the differences of age as well as genotype in regards to the severity of behavioral symptoms in Prader-Willi syndrome (PWS), with emphasis on the comparison between youngadults and adults.The Food Related Problem Questionnaire (FRPQ), the Aberrant Behavior Checklist Japanese Version (ABC-J), and the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) were administered to 46 PWS patients, including 33 young adults (ages 18–28) and 13 adults(ages 30–45). To examine the differences between young adults and adults, Mann-Whitney U tests were conducted. Statistically ...
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Prenatal exposure to androgens during brain development in males may participate to increase their susceptibility to develop neurodevelopmental disorders (ND) such as autism spectrum disorders (ASD) or intellectual disability (ID). However, little is known about the action of androgens in human neural cells. Methods: We used human neural precursors (hNSCs) differentiated from embryonic stem cells to investigate targets of androgens.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Priority Communication Source Type: research
ConclusionWe found a clear reversed gender difference in ASD symptomatology in persons with SMS. This may be relevant in the search for female protective factors assumed to explain the male bias in ASD.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
The family of a Maine student with autism and a rare neurological syndrome that affects his speaking ability is fighting for him to be able to carry an audio-recording device at school to ensure he's being treated properly
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Rates of U.S. autism spectrum disorder (ASD) diagnosis may be stabilizing, report Time and other news outlets, who base their reports on a research letter from JAMA. The letter reviews 2014 through 2016 data from the National Health Interview Survey (NHIS), which indicate that the prevalence rate for ASD remains statistically flat. It holds at 2.4 percent for U.S. children and adolescents.  Information in the report was based on in-person household interviews, with mostly parents reporting on ASD diagnoses among 30,502 children and adolescents. The report lists the prevalence rate for boys as 3.54 percent and for girl...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: News Speech-Language Pathology Autism Spectrum Disorder Language Disorders Research Speech Disorders Source Type: blogs
Conclusions: Results from this large case–control study with prospectively collected prenatal measurements do not support the hypothesis that prenatal exposure to PFAS is positively associated with ASD or ID. https://doi.org/10.1289/EHP1830 Received: 28 February 2017 Revised: 22 November 2017 Accepted: 24 November 2017 Published: 2 January 2018 Address correspondence to K. Lyall, A.J. Drexel Autism Institute, 3020 Market St., Suite 560, Philadelphia, PA 19104-3734 USA. Telephone: (215) 571-3215. Email: kld98@drexel.edu *Current affiliation: McKesson Corporation, 1 Post St., San Francisco, CA 94104 USA. Supplemen...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions Our results support the prevalence of off-label use of AP agents in managing various childhood psychopathologies also in Turkey. Further studies from multiple centers and using reliable and valid measurements are needed to determine the extent and predictors of AP use in outpatient samples from different child and adolescent centers.
Source: Clinical Neuropharmacology - Category: Neurology Tags: Original Articles Source Type: research
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