Salivary α‐amylase as a marker of stress reduction in individuals with intellectual disability and autism in response to occupational and music therapy

ConclusionsNot only do these results confirm the stress‐reducing nature of two types of multisensory therapy, but they support the use of sAA as a potential tool for evaluating stress levels in individuals with intellectual disability and autism spectrum disorder, providing an important physiological lens that may guide strategies in clinical and non‐clinical care for individuals with disabilities.
Source: Journal of Intellectual Disability Research - Category: Disability Authors: Tags: Brief Report Source Type: research

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Publication date: Available online 22 April 2019Source: Stem Cell ResearchAuthor(s): Rosa Montes, Pilar Mollinedo, Sonia Perales, Domingo Gonzalez-Lamuño, Veronica Ramos-Mejía, Jose L. Fernandez-Luna, Pedro J. RealAbstractADNP syndrome is an intellectual disability associated with Autism spectrum disorder caused by mutations in ADNP. We generated an iPSC line from an ADNP syndrome pediatric patient harboring the mutation p.Trp719* (GENYOi004-A). Peripheral blood mononuclear cells were reprogrammed using a non-transmissible form of Sendai viruses expressing the four Yamanaka factors (Oct3/4, SOX2, KLF4 and c-M...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
This study explored the impact of motivation on the memory for delayed intentions (so-called, prospective memory, PM) in autistic individuals. Specifically, we were interested in the effects of personal (i.e., receiving a reward) as compared to social motivation (i.e., performing a favour for someone). Given the well-established theory of mind deficits in autism, we expected autistic individuals to benefit more strongly from personal than social importance manipulations, whereas the opposite pattern was predicted for controls. Sixty-one adolescents with autism and 61 typically developing adolescents participated, with each...
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
In this report, we describe the case of a 14-year-old female Italian proband affected by ASD, carrying a novel ~ 270 kb interstitial microduplication, localized at the distal portion of the 4q13.1 region. The rearrangement was inherited from a mild symptomatic father and included a large part of the single EPHA5 gene, a receptor tyrosine kinase involved in the neural development, already indicated to be linked to ASD by previous Genome Wide Association Studies. This imbalance represents, to the best of our knowledge, the smallest duplication identified to date that only impacts the EPHA5 gene. We hypothesize ...
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
Magnetic Resonance Imaging (MRI) can now be used in conjunction with machine learning to predict cognitive development in infants,  according to a  studyrecently published inNeuroImage.White matter is intrinsic to developing brain activity, and the white matter connectome at birth can be used as a neuroimaging biomarker to calculate cognitive development. The group of researchers led by Jessica B. Girault, PhD, from the Carolina Institute for Developmental Disabilities at the University of North Carolina Chapel Hill are searching for imaging biomarkers like white matter to determine risks for neuropsychiatric con...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Publication date: Available online 19 April 2019Source: Social Science &MedicineAuthor(s): Máire LeanemAbstractExtended longevity among adults with Intellectual Disabilities (ID) and increasing rates of diagnosis of Autism Spectrum Disorders (ASD) mean that parents are unlikely to remain primary carers throughout the lifecourse of adults with ID and ASD. In the context of decreased funding for disability services and policy moves toward de-congregated living, non-disabled (ND) siblings of people with ID/ASD are increasingly likely to be drawn into support and care roles for their siblings. Drawing on literature ...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
(Cold Spring Harbor Laboratory Press) Written and edited by experts in the field, 'Next-Generation Sequencing in Medicine' from Cold Spring Harbor Laboratory Press examines next-generation sequencing technologies and their use, particularly in translational research. The contributors discuss the various sequencing platforms, their capabilities, and their applications in both research and clinical practice. The roles of next-generation sequencing in diagnosing autism and intellectual disabilities, monitoring cancers during disease progression, and determining the most appropriate drug treatments for patients are also covered.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Variants in the chromodomain helicase DNA-binding protein 8 (CHD8) have been associated with intellectual disability (ID), autism spectrum disorders (ASD) and overgrowth and CHD8 is one of the causative genes for OGID (overgrowth and ID). We investigated 25 individuals with CHD8 protein truncating variants (PTVs), including 10 previously unreported patients and found a male to female ratio of 2.7:1 (19:7) and a pattern of common features: macrocephaly (62.5%), tall stature (47%), developmental delay and/or intellectual disability (DD/ID, 81%), autism spectrum disorders (ASD, 84%), sleep difficulties (50%)...
Source: Clinical Genetics - Category: Genetics & Stem Cells Authors: Tags: Clin Genet Source Type: research
The government wants to know how we can make sure that health and social care staff have the right training to understand the needs of people with a learning disability and autistic people, and make reasonable adjustments to support them.
Source: NHS Networks - Category: UK Health Source Type: news
The nursing regulator has highlighted the importance of protected time for new training for nurses on working with people with learning disabilities and autism.
Source: Nursing Times - Category: Nursing Source Type: news
Conclusions Implications include the need for clinicians to (a) familiarize themselves with the varying views of autism held within the autistic community, (b) reflect on the language used to talk about autism and listen to how clients and/or their caregivers talk about it, and (c) consider the exploration of potential positive dimensions of autistic traits. PMID: 30995116 [PubMed - as supplied by publisher]
Source: American Journal of Speech-Language Pathology - Category: Speech-Language Pathology Authors: Tags: Am J Speech Lang Pathol Source Type: research
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