GABA alterations in pediatric sport concussion

Conclusions: GABA/Cre appears increased in a region colocalized with working memory task activation after sport concussion. Further work extending these results in larger samples and at time points across the injury episode will aid in refining the clinical significance of these observations.
Source: Neurology - Category: Neurology Authors: Tags: fMRI, MRS, Adolescence, Brain trauma ARTICLE Source Type: research

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ConclusionsResults from this pilot study suggest that early cognitive alterations and structural brain lesions affect a considerable percentage of patients with post-concussion syndrome following mTBI.ResumenIntroducciónLos traumatismos craneoencefálicos leves (TCE-L) han sido tradicionalmente considerados acontecimientos sin repercusiones cerebrales significativas, cuya sintomatología remite espontáneamente en unos días. Sin embargo, estos hechos son cada vez más cuestionados. Este estudio pretende objetivar la existencia de alteraciones cognitivas precoces en una serie de pacient...
Source: Neurologia - Category: Neurology Source Type: research
Publication date: 2018Source: NeuroImage: Clinical, Volume 19Author(s): William T. McCuddy, Lezlie Y. España, Lindsay D. Nelson, Rasmus M. Birn, Andrew R. Mayer, Timothy B. MeierAbstractAcute mood disturbance following sport-related concussion is common and is known to adversely affect post-concussion symptoms and recovery. The physiological underpinnings of depressive symptoms following concussion, however, are relatively understudied. We hypothesized that functional connectivity of the emotional processing network would be altered in concussed athletes and associated with the severity of depressive symptoms follow...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsAdolescents with elevated depressive symptoms engaged brain regions subserving evaluative processing of social interactions. This finding provides insight into the role the environment plays in contributing to the cognitive demands placed on adolescents recovering from concussion.
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Publication date: 2018Source: NeuroImage: Clinical, Volume 19Author(s): William T. McCuddy, Lezlie Y. España, Lindsay D. Nelson, Rasmus M. Birn, Andrew R. Mayer, Timothy B. MeierAbstractAcute mood disturbance following sport-related concussion is common and is known to adversely affect post-concussion symptoms and recovery. The physiological underpinnings of depressive symptoms following concussion, however, are relatively understudied. We hypothesized that functional connectivity of the emotional processing network would be altered in concussed athletes and associated with the severity of depressive symptoms follow...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsAdolescents with elevated depressive symptoms engaged brain regions subserving evaluative processing of social interactions. This finding provides insight into the role the environment plays in contributing to the cognitive demands placed on adolescents recovering from concussion.
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Scandinavian Journal of Medicine&Science in Sports,Volume 0, Issue ja, -Not available-.
Source: Scandinavian Journal of Medicine and Science in Sports - Category: Sports Medicine Authors: Source Type: research
Conclusions Initial results are consistent with the hypothesis that cortical glucose metabolism is elevated and oxidative metabolism is depressed in the acute phase following sports concussion, and normalizes as recovery progresses. This may be related to previously reported large lactate-to-pyruvate ratio in TBI patients as a consequence of mitochondrial dysfunction. Ongoing imaging of study participants will establish the statistical significance and clinical relevance of these findings. We gratefully acknowledge a FUSION Award from the Stony Brook School of Medicine and the Office of the Vice President for Research for ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Psychiatry and Specialized Neurology Imaging Source Type: research
1188Objectives: raumatic brain injury (TBI) due to contact sports is the cause of more than 200,000 emergency room visits and 1.7 million reported new cases each year in the United States, which contributes to one third of all deaths due to injury. Almost 75% of all reported TBIs are mild traumatic brain injury (mTBI) or concussion, although the number of unreported mTBIs remains unknown. Sports-related repetitive mild TBI may lead to chronic variations in mood, behavioral, and cognition. Studies of retired athletes in contact-sports, such as National Football League (NFL) players, show a higher rate of personality, behavi...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
Publication date: Available online 9 May 2018 Source:NeuroImage: Clinical Author(s): William T. McCuddy, Lezlie Y. España, Lindsay D. Nelson, Rasmus M. Birn, Andrew R. Mayer, Timothy B. Meier Acute mood disturbance following sport-related concussion is common and is known to adversely affect post-concussion symptoms and recovery. The physiological underpinnings of depressive symptoms following concussion, however, are relatively understudied. We hypothesized that functional connectivity of the emotional processing network would be altered in concussed athletes and associated with the severity of depressive symptoms...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusion: A normal GCS score and a SAC score do not exclude the possibility of significant intracranial injury.
Source: The Journal of Head Trauma Rehabilitation - Category: Neurology Tags: Focus on Clinical Research and Practice Source Type: research
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