The complex high-density lipoprotein proteome: a matter of purification?

We read with great interest the study by Rubinow  et al.1 on kidney function in association with alteration in the proteome of high-density lipoprotein (HDL), extending previous proteomic results2,3 to earlier stages of chronic kidney disease. However, we do not agree with the presentation and interpretation of the data for the following reasons . First, no quantitative raw data have been provided for proteins identified by mass spectrometry. Therefore, it is not possible for the reader to judge the quality of HDL preparations and the abundance of the individual proteins.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research