The triad of pruritus, xanthomas, and cholestasis: Two cases and a brief review of the literature

Abstract When encountered in children, xanthomas are most commonly associated with a group of disorders known as familial hyperlipidemias. Aside from cosmetic concerns, these xanthomas are typically asymptomatic, but when generalized pruritus is a prominent associated symptom, clinicians should consider a different set of diagnoses that includes cholestasis of the liver. In this article we present two illustrative cases of children with cholestatic disease, pruritus, and xanthomas and discuss other disorders that may include this triad.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fpde.13306

Source: Pediatric Dermatology - November 16, 2017 Category: Dermatology Authors: Hadley J. Pearson, Joy L. Mosser, Stephanie K. Jacks Tags: CASE REPORT Source Type: research