Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.

In this study, we examined the expression patterns of Gas1, Cdon, and Boc, as well as that of Ptch1, in the developing mouse inner ear from otocyst (embryonic day (E) 9.5) until birth and in the developing middle ear at E15.5. Ptch1, a readout of Hh signaling, was expressed in a graded pattern in response to Shh signaling throughout development. Expression patterns of Gas1, Cdon, and Boc differed from that of Ptch1, and each Hh co-receptor was expressed in specific cells and domains in the developing inner and middle ear. These unique and differential expression patterns of Hh co-receptors suggest their roles in mediating various time- and space-specific functions of Shh during ear development.
PMID: 29139542 [PubMed - in process]

Source: International Journal of Developmental Biology - November 16, 2017 Category: Biology Tags: Int J Dev Biol Source Type: research