Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice

Some of the antidepressant-like effects of ventromedial prefrontal cortex (vmPFC) deep brain stimulation (DBS) in rodents have been attributed to the modulation of prefrontal-raphe pathways. This is largely different from selective serotonin reuptake inhibitors (SSRIs), which increase serotonin (5-HT) levels by inhibiting the serotonin transporter (SERT). SSRIs have limited efficacy when given to SERT knockout (KO) mice, or patients with mutations in the serotonin transporter promoter gene (5-HTTLPR).

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 15, 2017 Category: Neurology Authors: Tatiana Bregman, Christina Nona, Julien Volle, Mustansir Diwan, Roger Raymond, Paul J. Fletcher, Jos é N. Nobrega, Clement Hamani Source Type: research