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45th Annual Meeting of the European Society for Blood and Marrow Transplantation

45th Annual Meeting of the European Society for Blood and Marrow TransplantationDate: Monday, November 13, 2017Year: 2019Location: Frankfurt, GermanyContent-type: current_conferences
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Lymphangioleiomyomatosis (LAM) is a rare low-grade neoplasm with lung cysts formation. Some patients with progressive disease need lung transplantation (LT). Herein we describe clinical characteristics and post operative outcomes of LT in LAM patients at a Brazilian reference centre. Our retrospective study included 11 LAM patients submitted to LT at University of Sao Paulo from 2003 to 2016 (91% double-lung). Mean follow-up after LT was 44 months. Mean age at LT was 43 ± 7 years. Preoperatively, patients presented dyspnea (100%), supplemental oxygen use (91%), pneumothorax (36%) and pulmonary hypertension (36%). On...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
Conclusion: PPFE may present in earlier or advanced stages and coexist with other patterns of ILD; in this setting histological characterization of different patterns may be important. Thoracic CNB and CB may be alternative diagnostic methods in patients not amenable for surgical lung biopsy.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
Introduction: Hospital re-admissions after lung transplant (LT) negatively affect quality of life, and costs. Reports on ICU readmission (ICU-r) have been limited to short series.Methods: Prospective, multicenter, observational study including 174 consecutive LT adults requiring ICU readmission (august 2012-16). We evaluated epidemiological features of this population and studied the outcomes. T student was used for statistical comparisons.Results: Overall, 118 (68.2%) ICU-r were due to acute respiratory failure (ARF) and 78 (44.8%) had an infectious cause, with pneumonia the most prevalent (73%). Acute cellular and humora...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
This article is protected by copyright. All rights reserved.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
Abstract Invasive aspergillosis rarely involves the thoracic aorta and is associated with a poor prognosis. A 56-year-old heart transplant recipient presented with invasive aspergillosis, primary Aspergillus aortitis, and a ruptured thoracic aorta pseudoaneurysm. Open surgical repair was not possible because of severe sepsis. Therefore, a sequential surgical strategy was planned, including emergency thoracic endovascular aortic repair, followed by antifungal treatment and definitive open repair with explantation of the endograft and placement of a cryopreserved arterial allograft under extracorporeal membrane oxyg...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Abstract In patients with haematological malignancies, bronchoalveolar lavage fluid specimens (BALF) are commonly used for the diagnosis of mould infections. However, it is not clear whether the cellular pellet (P) or the supernatant fraction (S) of the BALF is optimal for molecular diagnostic testing. Thus, 99 BALF specimens from 96 haematology patients with or without allogeneic hematopoietic stem cell transplant were collected. Pellets and supernatants were processed alone and in combination (S/P) by two fungal-specific real-time PCR assays compliant with international recommendations. S/P revealed superior res...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: J Clin Microbiol Source Type: research
AbstractOrgan transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e.g., malignant melanoma. It also offers an opport...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: The IFI incidence and mortality rate were similar to that reported in the literature. The IFI rate was higher in the group using prophylaxis, as this is a high-risk group. Although the IFI rate was not significantly different between groups using prophylaxis, patients should be followed closely for the effective use of posaconazole prophylaxis. PMID: 29151329 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Abstract Fungal arteritis affecting graft arteries is a rare but life‐threatening complication in kidney transplantation (KT). Here, we report the case of a patient with Aspergillus arteritis who experienced renal artery rupture 8 days after KT. We also reviewed 50 other reported cases of fungal arteritis after KT. We found that fungal contamination can occur during kidney graft harvest, preservation, and/or transplantation. Typically, early diagnosis, timely antifungal treatment, and emergency surgery seem crucial for avoiding life‐threatening vascular complications.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Tags: CASE REPORT Source Type: research
ConclusionsWe suggest the use of POS‐Tab is appropriate for prophylaxis and therapy of Aspergillus infections in LTx‐recipients, since POS‐Tab displayed more reliable PTLs with no added adverse events. However, we recommend regular drug monitoring for POS‐Liq and for therapy with POS‐Tab and that immunosuppressant levels are monitored closely when the posaconazole formulation is switched.This article is protected by copyright. All rights reserved.
Source: Mycoses - Category: Research Authors: Tags: Original Article Source Type: research
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