Reduced dorsolateral prefrontal cortex activation during affective Go/NoGo in violent schizophrenia patients: An fMRI study

We investigated the influence of anger processing on cognitive control in male schizophrenia patients presenting violent behaviors. We recruited 23 patients without and 24 patients with (SCZ+V) a history of violent behaviors, as well as 22 healthy non-violent men. Participants were administered an affective (angry-neutral faces) Go/NoGo task while undergoing functional magnetic resonance imaging. We found a reduced activation in the dorsolateral prefrontal cortex in SCZ+V patients specifically when inhibiting a response while viewing angry faces.

Source: Schizophrenia Research - November 9, 2017 Category: Psychiatry Authors: Andr às Tikàsz, Stéphane Potvin, Stéphane Richard-Devantoy, Olivier Lipp, Sheilagh Hodgins, Pierre Lalonde, Ovidiu Lungu, Alexandre Dumais Source Type: research