In Vivo Models of RCC Genetically engineered mouse models in ccRCC

Payal Kapur, M.D. Associate Professor of Pathology and Urology, UTSW Group Leader Genitourinary Pathology, UTSW Kidney Cancer Program co-leader, Simmons Cancer Center discusses In Vivo Models of RCC G... Author: kidneycancer Added: 11/08/2017
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts

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This study was for kidney cancer, but the benefits of using 3D models for surgical planning will translate to many other types of cancer operations, such as prostate, lung, liver and pancreas.”The study ’s other authors are Dr. David Thiel, Mayo Clinic, Florida; Dr. Eric Wallen, University of North Carolina, Chapel Hill; Dr. Jennifer Linehan, John Wayne Cancer Institute, Providence Saint John’s Health Center, Santa Monica; Dr. Wesley White, University of Tennessee Medical Center, Knoxville; Dr. Ketan Badani, Icahn School of Medicine at Mount Sinai, New York; and Dr. James Porter, Swedish Urology Group, Se...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Publication date: Available online 17 September 2019Source: Journal of Advanced ResearchAuthor(s): Peio Errarte, Gorka Larrinaga, José I. LópezAbstractCancer-associated fibroblasts (CAF) are a cellular compartment of the tumor microenvironment with critical roles in tumor development. Fibroblast activation protein-α (FAP) is one of the proteins expressed by CAF and its immunohistochemical detection in routine practice is associated with tumor aggressiveness and shorter patient survival. For these reasons, FAP seems a good prognostic marker in many malignant neoplasms, including renal cell carcinoma (RCC...
Source: Journal of Advanced Research - Category: Research Source Type: research
Contributors : Jarno Drost ; Marcel KoolSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensKidney tumours are among the most common solid tumours in children, comprising several distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first paediatric cancer organoid biobank. It contains tumour and matching normal kidney organoids from over 50 children with different subtypes of kidney cancer, including Wilms tumours, malignant rhabdoid tumours, renal...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): M. Aboelmagd, S. Anderson, S. O’Meara, S. Considine, M. Godson-Treacy, SK. O’Malley, D. Galvin, N. Hegarty, S. Connolly
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Cancers, Vol. 11, Pages 1394: Interleukin4Rα (IL4Rα) and IL13Rα1 Are Associated with the Progress of Renal Cell Carcinoma through Janus Kinase 2 (JAK2)/Forkhead Box O3 (FOXO3) Pathways Cancers doi: 10.3390/cancers11091394 Authors: Mi-Ae Kang Jongsung Lee Sang Hoon Ha Chang Min Lee Kyoung Min Kim Kyu Yun Jang See-Hyoung Park Specific kinds of interleukin (IL) receptors are known to mediate lymphocyte proliferation and survival. However, recent reports have suggested that the high expression of IL4Rα and IL13Rα1 in tumor tissue might be associated with tumorigenesis i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
The objective of the study presented was to search for further arguments in favor of an SSM with isPM. For that purpose, the factor’s histology, grading, and singular/multiple pancreas metastases were analyzed on the basis of 814 observations published up to 2018. While histology and grading allowed for no conclusions regarding the importance of an SSM, the comparison of singular/multiple pancreas metastases produced arguments in favor of an SSM: 1. The multiple pancreas metastases observed in 38.1% prove that multiple tumor cell embolisms occur with isPM, the exclusive “maturation” of which i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Condition:   Metastatic Renal Cell Carcinoma Interventions:   Drug: Ipilimumab;   Radiation: SBRT Sponsors:   Ontario Clinical Oncology Group (OCOG);   Bristol-Myers Squibb Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A total of $1.3 million awarded to advance new treatments for kidney cancerHOUSTON– September 16, 2019– The Kidney Cancer Association (KCA) is pleased to announce the recipients of the Advanced Discovery Awards (ADA) and Young Investigator Awards (YIA). In April, the KCA approved $1.3 million in new grant funding to advance early detection and new treatments for kidney cancer. “The KCA was delighted by the high caliber of proposals received for both awards and are hopeful that this research will advance the medical community’s understanding of kidney cancer,” said Dr. Christopher Wood, Ch...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
To determine whether use of renal mass biopsy may be associated with a reduction in surgery for patients with small, localized renal cell carcinoma (cT1aN0M0), especially among older patients and patients with greater comorbidity burden.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correlations with clinicopathological characteristics of ccRCC using mRNA expression data from The Cancer Genome Atlas kidney clear cell carcinoma (TCGA KIRC) cohort and a Korean ccRCC cohort. mRNA levels of DICER1, DROSHA, and DGCR8 were significantly decreased in both cohorts. However, AGO2 was significantly downregulated only in the Korean ccRCC cohort. Additionally, positive correlations were observed between th...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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