[Research Article] MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

Activating a deacetylase may overcome resistance to a receptor-targeted inhibitor in some breast cancer patients.

Source: Signal Transduction Knowledge Environment - July 30, 2014 Category: Science Authors: Umadevi Thirumurthi, Jia Shen, Weiya Xia, Adam M. LaBaff, Yongkun Wei, Chia-Wei Li, Wei-Chao Chang, Chung-Hsuan Chen, Hui-Kuan Lin, Dihua Yu, Mien-Chie Hung Source Type: news