Relationships between Circulating and Intraprostatic Sex Steroid Hormone Concentrations

Conclusions: Circulating concentrations of sex steroid hormones are poor surrogate measures of the intraprostatic hormonal milieu.
Impact: The high exposure misclassification provided by circulating sex steroid hormone concentrations for intraprostatic levels may partly explain the lack of any consistent association of circulating hormones with prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 26(11); 1660–6. ©2017 AACR.

Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Cook, M. B., Stanczyk, F. Z., Wood, S. N., Pfeiffer, R. M., Hafi, M., Veneroso, C. C., Lynch, B., Falk, R. T., Zhou, C. K., Niwa, S., Emanuel, E., Gao, Y.-T., Hemstreet, G. P., Zolfghari, L., Carroll, P. R., Manyak, M. J., Sesterhann, I. A., Levine, P. H. Tags: Research Articles Source Type: research