Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease
Nature Neuroscience 20, 1514 (2017).
doi:10.1038/nn.4660
Author: Subhojit Roy
Mouse models have generally failed to recapitulate the dopaminergic neurodegeneration seen in Parkinson's disease. Expressing mutant α-synuclein in a background of elevated dopamine generates mice with nigrostriatal degeneration.
Source: Nature Neuroscience - Category: Neuroscience Authors: Subhojit Roy Tags: News and Views Source Type: research