Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease

Nature Neuroscience 20, 1514 (2017). doi:10.1038/nn.4660 Author: Subhojit Roy Mouse models have generally failed to recapitulate the dopaminergic neurodegeneration seen in Parkinson's disease. Expressing mutant α-synuclein in a background of elevated dopamine generates mice with nigrostriatal degeneration.
Source: Nature Neuroscience - Category: Neuroscience Authors: Tags: News and Views Source Type: research