MiR-34c-5p and CaMKII are involved in aldosterone-induced fibrosis in kidney collecting duct cells.

In conclusion, aldosterone-induced down-regulation of miR-34c-5p in the Wnt signaling and consequent increase of CaMKIIβ expression are likely to be involved in aldosterone-induced fibrosis.
PMID: 29070573 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Park EJ, Jung HJ, Choi HJ, Cho JI, Park HJ, Kwon TH Tags: Am J Physiol Renal Physiol Source Type: research