Low-Dose Tissue Plasminogen Activator in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Intravenous thrombolysis using tissue plasminogen activator (tPA) improves significantly the neurologic function in patients with acute ischemic stroke (AIS). However, it brings financial burden to patients and is associated with symptomatic intracranial hemorrhage (SICH). Whether low-dose tPA can effectively reduce SICH and has the same efficacy as standard-dose tPA is still controversial.

Source: Journal of Stroke and Cerebrovascular Diseases - October 27, 2017 Category: Neurology Authors: Ji-Wei Cheng, Xiao-Jing Zhang, Li-Shan Cheng, Guo-Yi Li, Li-Jun Zhang, Kang-Xiang Ji, Qing Zhao, Yu Bai Source Type: research