Application of miscibility analysis and determination of Soluplus solubility map for development of carvedilol-loaded nanofibers

Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Olivera Kaljević, Jelena Djuris, Bojan Čalija, Zoran Lavrič, Julijana Kristl, Svetlana Ibrić Electrospinning was used to produce carvedilol-loaded Soluplus polymer nanofibers using a systematic approach. Miscibility between drug and polymer was determined through calculation of the interaction parameter, χ, and the difference between the total solubility parameters, Δdt . A solubility map for Soluplus was obtained by examining different solvent systems, carrying out electrospinning, and characterizing the nanofibers formed. Miscibility studies showed that carvedilol and Soluplus can form a miscible system (χ =−2.3054; Δδt < 7.0MPa1/2). Based on the Soluplus solubility map, acetone: chloroform (90:10; w/w) represents a suitable solvent system for electrospinning of carvedilol-loaded Soluplus nanofibers. Scanning electron microscopy of these nanofiber samples showed smooth surface morphology. The nanofibers had a regular cylindrical morphology. Beads appeared along the nanofibers more frequently in formulations with lower percentages of carvedilol. Differential scanning calorimetry showed no melting endothermic peak for carvedilol, which suggests its complete conversion from the crystalline to the amorphous form (at polymer: carvedilol 1:1). The infrared spectrum of the carvedilol-loaded Soluplus nanofibers showed no characteri...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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ConclusionThe common genetic variation in NKG2D does not correlate significantly with sporadic CC risk. This is in contrast to the previous positive findings in the Scandinavian study with PSC-patients. The failure to reproduce the association may reflect an important difference between the pathogenesis of sporadic CC and that of PSC-related CC. Given that genetic susceptibility is likely to be multifaceted and complex, further validation studies that include both sporadic and PSC-related CC are required.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
ConclusionAlthough patients with MYC-R lymphoma have been reported to be at high risk of primary treatment failure, this was not predicted by iPET+ results. Thus, the iPET result should not be used to guide changes in front-line or consolidative therapy for these patients.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
ConclusionsSemiquantitative analysis of FDG PET/CT may be used in detecting recurrent disease of patients with colorectal carcinoma. Eliminating interfering physiological colonic activity in analysis may have an incremental effect on the success of this technique, by means of increasing the specificity.ResumenObjetivoLa recurrencia del cáncer colorrectal aparece principalmente en los primeros 2 años después de la cirugía. El sitio de recidiva más frecuente es la región posquirúrgica y su entorno. El propósito de este estudio fue evaluar la utilidad del ...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Publication date: September 2018Source: Nano Energy, Volume 51Author(s): Yun Zheng, Yifeng Li, Tong Wu, Wenqiang Zhang, Jianxin Zhu, Zhanping Li, Jing Chen, Bo Yu, Jianchen Wang, Jiujun ZhangAbstractSolid-oxide fuel cells (SOFCs) are clean and highly efficient electrochemical energy conversion devices and in this study, novel nanolayer-structured cathodes with Nd0.5Sr0.5CoO3-δ/Nd0.8Sr1.2CoO4±δ heterointerfaces for intermediate-temperature SOFCs are developed in which significantly enhanced oxygen reduction reaction (ORR) kinetics are obtained by increasing the interface layers. The electrical surface exc...
Source: Nano Energy - Category: Nanotechnology Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Mehdi Kheradmandfard, Seyed Farshid Kashani-Bozorg, Amir Hosein Noori-Alfesharaki, Anoushe Zargar Kharazi, Mansooreh Kheradmandfard, Narges AbutalebiAbstractForsterite (Mg2SiO4) has recently attracted considerable attention in different fields because of its wide range of applications. In this paper, pure forsterite nanopowders were synthesized by an ultra-fast, highly efficient and green method for the first time. Microwave irradiation was used to synthesize forsterite nanopowder. The formation of highly crystalline forsteri...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Sandro B. Bitencourt, Daniela M. dos Santos, Emily V.F. da Silva, Valentim A.R. Barão, Elidiane C. Rangel, Nilson C. da Cruz, Grace M. de Souza, Marcelo C. Goiato, Aldiéris A. PesqueiraAbstractThe aim of this study was to develop and characterise a new plasma-enhanced chemical vapor deposition (PECVD) film for improving shear bond strength (SBS) between yttria-stabilised tetragonal zirconia (Y-TZP) and veneering ceramic. In total, 192 Y-TZP samples (13 × 5.4 × 5 mm) were divided into 6 grou...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Kalimuthu Kalishwaralal, Subhaschandrabose Jeyabharathi, Krishnan Sundar, Sethuraman Selvamani, Mahendran Prasanna, Azhaguchamy MuthukumaranAbstractCardiomyopathy is the leading cause of mortality in the world and economic burdens on national economies. A cardiac patch approach aims at regenerating an infracted heart by providing healthy functional cells to the injured region via a film carrier substrate, and providing mechanical and electrical support. Selenium acts as an important element in the prevention and treatment of ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Kenta Yamanaka, Manami Mori, Yasuhiro Torita, Akihiko ChibaAbstractThe addition of carbon and silicon as minor alloying elements was examined as a means to improve the mechanical properties of novel nitrogen-doped Co–Cr-based alloy dental castings. Samples of Co–32Cr–9W–Si–0.25N–C (mass%) alloys were prepared using a dental-casting machine. Microstructural analysis was performed on the alloys using scanning electron microscopy, electron-backscatter diffraction, electron-probe microanalysis,...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 20 July 2018Source: Materials Science and Engineering: AAuthor(s): Bo Gao, Qian Xiang, Tianfu Guo, Xu Guo, Shan Tang, Xiao Xu HuangAbstractMore precise modeling on ductile fracture of metals at the scale from micron to meter is still urgently needed in many engineering applications. Due to the variety of metal and its alloys, a lack of understanding on the mechanisms and quantitative experimental data impede building and assessing mechanics models for ductile fracture at different length scales. In this paper, in situ tensile tests are carried out in Transmission Electronic Microscope (TE...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Babak Roushangar Zineh, Mohammad Reza Shabgard, Leila RoshangarAbstractUse of artificial cartilage due to its poor regenerative characteristics is a challenging issue in the field of tissue engineering. In this regard, three-dimensional printing (3D) technique because of its perfect structural control is one of the best methods for producing biological scaffolds. Proper biomaterials for cartilage repairs with good mechanical and biological properties and the high ability for 3D printing are limited. In this paper, a novel bio...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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